The Impact of Vaginal Profile During Ovarian Stimulation on the IVF/ICSI Outcome: a Prospective Observational Study
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- clinical pregnancy rate
研究概览
简要总结
Vaginal flora is closely related to female reproductive health. Previous studies have suggested that the composition of the vaginal flora is related to the pregnancy outcomes, and abnormalities in the vaginal flora lead to a decrease in the success rate of IVF. During the IVF treatment, the hormone level changes far exceed the physiological level. What changes will happen to the vaginal flora? Does IVF treatment itself affect the vaginal flora and affect outcomes? This study used prospective cohort study to show the changes in vaginal flora during conventional IVF treatment, providing more evidence for revealing the relationship between vaginal flora and infertility treatment outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •20-40 years old
- •BMI<30kg/m2
- •First IVF/ICSI cycle (GnRH agonist or antagonist protocol)
- •no vaginitis after recruitment
- •completion of oocyte retrieval
- •Exclusion Criteria
- •history of RSA
- •history of endometriosis
- •Immune diseases such as SLE, etc., and the use of immunosuppressive agents, glucocorticoids, etc.
- •obvious hydrosalpinx(>2cm in diameter by ultrasound)
排除标准
- 未提供
结局指标
主要结局
clinical pregnancy rate
时间窗: 12.2019-03.2020
no. of clinical pregnancy / total number of embryo transfer cycles
次要结局
未报告次要终点
研究者
Haiyan Lin
Principal Investigator
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University