Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia

Recruiting

• Conditions: Multiorgan Failure; COVID-19 Pneumonia; SARS-CoV-2 Acute Respiratory Disease; Sepsis; Pneumonia
• Interventions: Diagnostic Test: Chest X-ray

• Registration Number: NCT05181696
• Lead Sponsor: Osijek University Hospital

Brief Summary

The research will be retrospective, and will include all patients who were admitted during 2020 and 2021 in the COVID-19 ICU of University Hospital Center Osijek due to pneumonia caused by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The association of chest x-ray infiltrate evolution with changes in laboratory inflammatory parameters and respiratory function parameters will be examined.

Detailed Description

The research will be retrospective, and will include a review of medical history of all patients admitted in the COVID-19 ICU of the University hospital Osijek during 2020 and 2021. Associated comorbidity, hospital admission date, intubation date, mechanical ventilation, extubation, discharge, and patient final outcome will be recorded for each patient. By analyzing X-rays of the lungs by radiology specialists, inflammatory infiltrates in the lungs will be quantified via the Brixia system, during hospital admission, admission to the Respiratory Center, and during treatment at the Respiratory Center. All patients will have their Sequential Organ Failure Assessment (SOFA) and/or Acute Physiology and Chronic Health Evaluation (APACHE II) values calculated upon admission. Inflammatory parameters (c-reactive protein (CRP), procalcitonin (PCT), interleukine-6 (IL-6), ferritin), red blood cell count, leukocytes, blood urea nitrogen (BUN), arterial blood gases and ventilation parameters on admission to the hospital, admission to the ICU, and on several occasions during treatment in the ICU will be analysed. Also, empirical use of antibiotics, the occurrence of bacterial superinfections, sepsis and organic failure will be noted.

Study Timeline

• Study Start: 2020-01-01
• Study First Submitted: 2022-01-04
• Study First Submitted QC: 2022-01-04
• Study First Posted: 2022-01-06
• Status Verified: 2023-07
• Last Update Submitted: 2023-07-14
• Last Update Posted: 2023-07-18
• Primary Completion: 2024-05
• Study Completion: 2024-05

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Pneumonia caused by SARS-CoV-2 virus
• Admission to the ICU COVID-19 unit

Exclusion Criteria

• Patients with lung tumors or history of lung resection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
COVID-19 pneumonia patients	Chest X-ray	Patients treated at the University Hospital Osijek Respiratory Center with pneumonia caused by SARS-CoV-2

Primary Outcome Measures

Name	Time	Method
Inflammatory markers	21 days	The influence of serum levels of inflammatory parameters, and clinical and laboratory indicators of organic failure on chest x-ray severity score will be examined
Chest x-ray severity score	21 days	The influence of the dynamics of radiographic changes quantified by Brixia score on the outcome of COVID-19 patients will be examined

Trial Locations

Locations (1)

University hospital Osijek; 🇭🇷 Osijek, Croatia