Preterm Lung Function and Exercise Response Measured by OEP
- Conditions
- Premature Birth
- Interventions
- Diagnostic Test: Lung function + exercise tests
- Registration Number
- NCT04239287
- Lead Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
- Brief Summary
This study will explore lung function and respiratory health in school-aged children who were born prematurely at \<32 weeks gestation. It will involve full lung function assessment, a questionnaire and discussion about respiratory health, and an exercise test using optoelectronic plethysmography (OEP) to measure breathing patterns.
- Detailed Description
Preterm are born during a critical stage of lung development, and can have abnormalities in lung function that persist with age. Previous studies have shown that children with BPD have reduced lung function and limited exercise capacity. These studies have used conventional lung function testing which requires a tight fitting mask. This is uncomfortable, may alter normal breathing patterns and cannot measure changes in total lung volume.
Optoelectronic plethysmography (OEP) indirectly measures lung volumes and breathing patterns using cameras to track the position of marker stickers on the chest, back and abdomen. It is comfortable, does not require a mask and allows us to track changes in total lung volume.
This study will use standard lung function testing and OEP to measure lung function and breathing patterns at rest and during exercise in school-aged children born prematurely, compared to healthy children born at full term. All participants will complete standard lung function tests, a questionnaire and structured interview to qualitatively assess respiratory health, and an exercise test using OEP to assess how breathing changes with exercise.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
- Age 8-16 years
- Born at <32 weeks gestation (preterm) or >37 weeks gestation (controls)
- Parental consent obtained
- Unable to comply with test procedure
- Respiratory illness within last 2 weeks
- Cardiac disease (excludes ligated PDA)
- Neuromuscular disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Preterm Lung function + exercise tests Children age 8-16 years born at \<32 weeks gestation. Control Lung function + exercise tests Children age 8-16 years born at \>37 weeks gestation
- Primary Outcome Measures
Name Time Method Change in end-expiratory lung volume with exercise Pre + post exercise (10minutes) Change in end-expiratory lung volume measured in litres with exercise measured using optoelectronic plethysmography
- Secondary Outcome Measures
Name Time Method Baseline activity levels 1 week period Baseline activity levels measured using Actigraph monitor
Change in tidal volume with exercise During exercise (10 minutes) Change in tidal volume with exercise measured in litres using optoelectronic plethysmography
Change in minute ventilation with exercise During exercise (10 minutes) Change in minute ventilation (measured in litres/minute) with exercise measured using optoelectronic plethysmography.
Forced vital capacity (FVC) Baseline Baseline forced vital capacity measured in litres (FVC)
Forced mid-expiratory flow (FEF25-75%) Baseline Mean forced expiratory flow between 25% and 75% of FVC measured in litres/second (FEF25-75%)
Baseline forced expiratory volume in 1 second (FEV1) Baseline Baseline forced expiratory volume (in litres) in 1 second measured by spirometry (FEV1)
Transfer factor for carbon monoxide (TLCO) Baseline Transfer factor for carbon monoxide (measured in millimoles per minute per kilopascal) using single breath test
Body plethysmography Baseline Baseline lung volume (in litres) measured using body plethysmography
FeNO Baseline Baseline FeNO (fraction of exhaled nitric oxide)
Exercise induced bronchoconstriction 10 minutes post exercise % change in FEV1
Trial Locations
- Locations (1)
Royal Victoria Infirmary
🇬🇧Newcastle, Tyne And Wear, United Kingdom