Identifikation and Evaluation of different gene loci for nsCL/P and nsCPO in a Vietnamese populatio

Recruiting

• Conditions: Q37.0; Q37.1; Q37.2; Q37.3; Q37.4; Q37.5; Q37.8; Q37.9; Q35.1; Cleft hard palate with bilateral cleft lip

• Registration Number: DRKS00006855
• Lead Sponsor: Geschäftsstelle der DGKFOUniversitätsklinikum GießenPoliklinik für Kieferorthopädie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-05-15
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

Patients, with nsCL/P or nsCPO
Patients, whose four grandparents are of Vietnamese descent.
written consent to participate in the study.

ASA-group 1-3.

Inclusion criteria control patients:

Patients, without a syndrome
Patients, whose four grandparents are of Vietnamese decent.
written consent to participate in the study.

ASA-group 1-3.

Exclusion Criteria

Exclusion criteria patient:

no written consent to participate in the study.

patients with a syndrome

ASA-group 4-8.

Exclusion criteria control:

Patients, with a CL/P or CPO or
signs of a CL/P or CPO

Relatives of a cleft patient

no written consent to participate in the study.

patients with a syndrome

ASA-group 4-8.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary end point of the study is to verify the identified genetic loci respectively identify further genetic loci or genes causative for non-syndromic cleft lip and palate (nsCLP) or cleft palate only (nsCPO) in a Vietnamese population.

Secondary Outcome Measures

Name	Time	Method
Evaluation of phenotyp-genotyp correlation