The identification of genetic variants in pedigrees with a high genetic loading for alcohol dependence

Completed

• Conditions: Addiction; alcohol dependence; 10037176

• Registration Number: NL-OMON40342
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 280

Inclusion Criteria

1. Patients who have given informed consent to participate and who at the screening visit have met all the below stated inclusion criteria.;Diagnosed with alcohol dependence according to DSM-IV criteria
Age between 16-85 years
Caucasian ethnicity (i.e., defined as having at least three Caucasian grandparents)
A positive family history of alcohol dependence;2. Relatives who have given informed consent to participate and who at the screening visit have met all the below stated inclusion criteria.;Age between 16-85 years
Caucasian ethnicity (at least three Caucasian grandparents)

Exclusion Criteria

Age below 16
Non-caucasian

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Addiction severity index (ASI), including demographic data<br /><br>Alcohol use disorders identification test (AUDIT)<br /><br>Cannabis use disorders identification test (CUDIT and additional items<br /><br>CUDIT-Revised)<br /><br>Fagerström test for Nicotine Dependence (FTND)<br /><br>Gambling section of the EuropASI versie III (see ASI)<br /><br>Compulsive Internet Use Scale (CIUS)<br /><br>Eating Disorder Examination Questionnaire (EDE-Q)<br /><br>Ethnicity<br /><br>Mini-plus (modules A-P)<br /><br>Adult ADHD Self-Report Scale (ASRS)<br /><br>Hospital Anxiety and depression scale (HADS)<br /><br>Family Interview for Genetic Studies (FIGS)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>NA</p><br>