Identification of germline mutations in familial and extremely early-onset urinary bladder cancer
Recruiting
- Conditions
- 10038364bladder cancerbladder papilloma
- Registration Number
- NL-OMON41769
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 585
Inclusion Criteria
Newly identified high-risk UBC families:
- Hereditary UBC: A family with at least three first-degree relatives with UBC, or a family with two first-degree relatives with UBC with uncommon characteristics (such as young never-smoking women with high-stage disease).;Early-onset patients:
- Diagnosed with bladder cancer after 01-01-1989
- <= 30 years old at time of diagnosis
Exclusion Criteria
High-risk UBC families:
- Unable to read or understand the invitation letter, information brochure and informed consent form;Early-onset patients:
- Unable to read or understand the invitation letter, information brochure and informed consent form
- Younger than 12 years at time of study invitation
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters are the presence of rare, novel, high-penetrance<br /><br>mutations predisposing for familial or early-onset bladder cancer, and<br /><br>second-hit (somatic) mutations (found in tumor DNA).</p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary study parameter is information on disease characteristics (tumor<br /><br>stage, tumor grade).</p><br>