Pre-workout Supplement Versus Caffeine on Energy Expenditure.

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: Nutricost caffeine powder; Dietary Supplement: Crystal Light; Dietary Supplement: ENGN Shred

• Registration Number: NCT04539054
• Lead Sponsor: Northern Illinois University

Brief Summary

The primary purpose of this study was to examine the acute effects of a multi-ingredient pre-workout supplement versus an ergogenic dose of caffeine (6 mg/kg) on energy expenditure during low-intensity exercise. The effects of these substances on substrate utilization, gas exchange, and psychological factors were also investigated. Twelve males (mean ± SD: age = 22.8 ± 2.4 years) completed three bouts of 60-min of treadmill exercise at 4.8-6.4 km/hr on separate days after consuming a pre-workout supplement, 6 mg/kg of caffeine, or placebo in a randomized fashion. The pre-workout and caffeine supplements resulted in significantly greater energy expenditure (p \< 0.001, p = 0.006, respectively), VO2 (p \< 0.001, p = 0.007, respectively), VCO2 (p = 0.006, p = 0.049, respectively), and VE (p \< 0.001, p = 0.007, respectively), but not rates of fat or carbohydrate oxidation or respiratory exchange ratio compared to placebo (collapsed across condition). In addition, the pre-workout supplement increased feelings of alertness (p = 0.015) and focus (p = 0.005) 30-minutes post-ingestion and decreased feelings of fatigue (p = 0.014) during exercise compared to placebo (collapsed across condition). Thus, the pre-workout supplement increased energy expenditure and measures of gas exchange to the same extent as 6 mg/kg of caffeine with concomitant increased feelings of alertness and focus and decreased feelings of fatigue.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-09-01
• Primary Completion: 2019-12-31
• Study Completion: 2019-12-31
• Status Verified: 2020-08
• Study First Submitted: 2020-08-26
• Study First Submitted QC: 2020-08-31
• Last Update Submitted: 2020-08-31
• Study First Posted: 2020-09-04
• Last Update Posted: 2020-09-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 12

Inclusion Criteria

• Male

Exclusion Criteria

• history of medical or surgical events, including cardiovascular disease, metabolic, renal, hepatic, or musculoskeletal disorders;
• use of any medications
• use of nutritional supplements
• habitual use of caffeine (≥1 caffeinated beverage per day)
• participation in another clinical trial or investigation of another investigational product within 30 days prior to screening/enrollment.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Caffeine Condition	Nutricost caffeine powder	This condition consisted of the ingestion of 6 mg of caffeine per kg of body mass.
Placebo condition	Crystal Light	This condition consisted of the ingestion of a placebo.
Pre-Workout Condition	ENGN Shred	This condition consisted of the ingestion of one serving of the pre-workout supplement.

Primary Outcome Measures

Name	Time	Method
Energy expenditure	Measured continuously during 60 minutes of exercise for all three supplement conditions	Measurement of caloric expenditure via gas exchange

Secondary Outcome Measures

Name	Time	Method
Oxygen consumption	Measured continuously during 60 minutes of exercise for all three supplement conditions	Measurement of rate of oxygen consumption using a metabolic cart
Minute ventilation	Measured continuously during 60 minutes of exercise for all three supplement conditions	Measurement of ventilation rate using a metabolic cart
Rate of carbohydrate oxidation	Measured continuously during 60 minutes of exercise for all three supplement conditions	Carbohydrate oxidation was estimated thru measurements of gas exchange
Feelings of focus	Baseline, 30-minutes post-ingestion of supplement, and at the 30-minute time point of exercise for all three supplement conditions	Subjects were asked to rate their feelings of focus using a 5-point Likert scale
Rate of fat oxidation	Measured continuously during 60 minutes of exercise for all three supplement conditions	Fat oxidation was estimated thru measurements of gas exchange
Carbon dioxide production	Measured continuously during 60 minutes of exercise for all three supplement conditions	Measurement of rate of carbon dioxide production using a metabolic cart
Feelings of fatigue	Baseline, 30-minutes post-ingestion of supplement, and at the 30-minute time point of exercise for all three supplement conditions	Subjects were asked to rate their feelings of fatigue using a 5-point Likert scale
Feelings of energy	Baseline, 30-minutes post-ingestion of supplement, and at the 30-minute time point of exercise for all three supplement conditions	Subjects were asked to rate their feelings of energy using a 5-point Likert scale
Feelings of alertness	Baseline, 30-minutes post-ingestion of supplement, and at the 30-minute time point of exercise for all three supplement conditions	Subjects were asked to rate their feelings of focus using a 5-point Likert scale

Trial Locations

Locations (1)

Exercise Physiology Laboratory; 🇺🇸 DeKalb, Illinois, United States