The effect of gaseous ozone therapy in addition to periodontal treatment on oxidative stress in individuals with type 2 diabetes: A double-blinded, randomized clinical trial

Albanian University0 个研究点目标入组 200 人开始时间: 2022年7月23日最近更新: 2023年5月29日

适应症

试验速览

2022 Results article in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775443/ results (added 13/01/2023) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37170229/ results (added 15/05/2023)

•1. Meet the type 2 diabetes mellitus (T2DM) diagnostic criteria recommended by the American Diabetes Association (ADA) in 2020:
•1.1. FPG =126 mg/dl (7.0 mmol/l), or 2-h PG =200 mg/dl (11.1 mmol/l) during OGTT, or HbA1C = 6.5 % (48 mmol/mol), or a random plasma glucose =200 mg/dl (11.1 mmol/l)
•2. Diagnosis of generalized periodontitis

•1. Declined cognitive function and unable to make informed consent
•2. Underwent periodontal treatment within the last 12 months
•3. Systemic antibiotic therapy within the last 6 months
•4. Pregnancy or breastfeeding
•5. Uncontrolled hypertension
•6. History of heart disease or stroke which might interfere with the systemic antioxidative status
•7. Active smokers (>10 cigarettes/daily)

发起方

Albanian University