The effect of catecholamines on intraoperative hemodynamics
- Conditions
- Patients > 45 years of age at-risk for cardiovascular complications undergoing moderate- to high-risk major open abdominal surgery.Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
- Registration Number
- EUCTR2022-001023-32-AT
- Lead Sponsor
- Medical University of Vienna
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- All
- Target Recruitment
- 225
1. = 45 years old
2. Scheduled for moderate- to high-risk major open abdominal surgery expected to last at least two hours
3. ASA physical status = 2
4. At least one of the following risk factors:
a. Age = 75 years
b. History of peripheral arterial disease
c. History of coronary artery disease
d. History of stroke or transient ischemic attack
e. History of chronic kidney disease
f. Diabetes requiring medical treatment
g. Current smoking or history of 15 pack-years
h. History of heart failure
i. Preoperative high-sensitivity Troponin T = 14ng.L-1
j. Preoperative NT-proBNP = 200 ng.L-1
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 55
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 170
1. Scheduled for pheochromocytoma surgery
2. Scheduled for liver and kidney transplantation
3. Requiring preoperative intravenous vasopressor medications
4. Contraindications to epinephrine, norepinephrine or phenylephrine per clinical judgement
5. Permanent atrial fibrillation
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method