Efficacy of haloperidol on symptom of opium withdrawal.

Phase 3

Recruiting

• Conditions: Opium use disorder.; Mental and behavioral disorders due to use of opioids_dependence syndrome

• Registration Number: IRCT201702131457N12
• Lead Sponsor: Mazandaran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 74

Inclusion Criteria

A reliable history of opioids consumptions until the onset of the study; DSM-5 criteria for opioid use disorder; Positive urine rapid test of opioids
Exclusion criteria:Enzyme inducers medication usage or other medical treatments;History of Sensitivity to haloperidol; Poly substance use (Cannabinoids ,Alcohol , barbiturates , benzodiazepines, analgesics) and use of antidepressants , other antipsychotics , beta blockers , alpha 2 agonists, inhibitors of CYP 3A4 , and CYP2D6 in the last month before study (except nicotine); Major depressive disorder, Bipolar mood disorder, severe anxiety disorders and Psychosis; Severe medical illnesses such as epilepsy, hepatitis, tuberculosis, AIDS, liver dysfunction, renal dysfunction; Pregnancy and Lactation; Electroconvulsive therapy in the last 6 months; Suicidal ideation or suicidal attempt at the beginning of the study or within the last 6 months; Mental retardation; Neurological disorder such as dementia, uncontrolled epilepsy and history of head trauma ; Past history of neuroleptic malignant syndrome.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Acute opioid withdrawal symptoms. Timepoint: every other day. Method of measurement: Objective opioid withdrawal scale.

Secondary Outcome Measures

Name	Time	Method
Extrapyramidal symptoms, serum prolactin level. Timepoint: Extrapyramidal symptoms will be assessed by everyday clinical assessment, prolactine; and serum prolactin level, before & after the end of the study. Method of measurement: History & Physical Exam & labratory test.