AccuIMR Predicts Microvascular Obstruction and Infarct Size in STEMI Patients

Completed

• Conditions: Coronary Artery Disease; STEMI - ST Elevation Myocardial Infarction; Microvascular Coronary Artery Disease

• Registration Number: NCT06947564
• Lead Sponsor: RenJi Hospital

Brief Summary

In this study, we aimed to investigate the clinical significance of the angiography-based IMR calculation method (AccuIMR) and its prognostic assessment capability by evaluating the concordance or discordance between AccuIMR values and cardiac magnetic resonance (CMR) results.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01-01
• Primary Completion: 2023-12-31
• Study Completion: 2024-12-31
• Status Verified: 2025-04
• Study First Submitted: 2025-04-20
• Study First Submitted QC: 2025-04-20
• Last Update Submitted: 2025-04-20
• Study First Posted: 2025-04-27
• Last Update Posted: 2025-04-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 843

Inclusion Criteria

• (1) STEMI patients who underwent PCI within 12 hours of symptom onset.
• (2) coronary microvascular function was assessed using contrast-enhanced CMR after PCI.

Exclusion Criteria

• (1) Suboptimal coronary angiographic images, including inadequate contrast opacification, unsatisfactory projection view, and severe overlap or distortion of the target vessel.
• (2) Lacking two angiographic projections separated by at least 25° apart post-PCI.
• (3) Inadequate CMR image quality

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
CMR	CMR was performed at a median of 5 days post-reperfusion.	Contrast-enhanced CMR was performed on a 3.0-T scanner (Achieva TX, Philips Healthcare, Best, The Netherlands) . All sequences were acquired during breath-hold with a field of view at 350 × 350 mm2. Two experienced readers, blinded to clinical data, evaluated the CMR results using validated software (QMass MR 7.5, Medis, Leiden, The Netherlands). The acquired images were utilized to assess ventricular parameters and calculate the left ventricular ejection fraction (LVEF).

Secondary Outcome Measures

Name	Time	Method
LDL-C, mmol/L	Blood samples were collected after a 12-hour fast in the second day post-PCI.	Low-density cholesterol (LDL-C) is the cholesterol in low-density lipoprotein (LDL), which reflects how much LDL is present.
HbA1c, %	Blood samples were collected after a 12-hour fast in the second day post-PCI.	Hemoglobin a1c (HbA1c) is the combination of hemoglobin and blood sugar. Its concentration in the blood is stable and is not affected by short-term blood sugar concentrations. Hemoglobin A1C has obvious clinical value in the diagnosis of diabetes.

Trial Locations

Locations (1)

Renji Hospital; 🇨🇳 Shanghai, Shanghai, China