Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Early Fluid Resuscitation in Patients With Septic Shock
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sepsis
- Sponsor
- Xiangya Hospital of Central South University
- Enrollment
- 62
- Locations
- 1
- Primary Endpoint
- change in SOFA score
- Last Updated
- 4 years ago
Overview
Brief Summary
Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Resuscitation in Patients With Septic Shock
Detailed Description
Objectives: Comparison of microcirculation indexes and hemodynamic indexes to guide resuscitation in patients with septic shock. Intervention: 1. Microcirculation-oriented resuscitation group: When the system hemodynamics meets the standard of EDGT, the microcirculation-oriented resuscitation group will evaluate the organ perfusion level and adjust the hemodynamic therapy according to the sublingual microcirculation parameters (PPV \> 68%). 2. Control group: The standard treatment group will adjust the shock management scheme through systemic hemodynamic parameters. Primary outcome: (1)change in SOFA score at 72h (2)30-day mortality
Investigators
Eligibility Criteria
Inclusion Criteria
- •patients fulfilled the diagnostic criteria of septic shock.
Exclusion Criteria
- •declined to participate
- •patients who were younger than 18 years old
- •active bleeding
- •septic shock is diagnosed for more than 4 hours
- •patients are expected to be die within 24hours
Outcomes
Primary Outcomes
change in SOFA score
Time Frame: 72h
△SOFA
Secondary Outcomes
- 30-day mortality(30d)