Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Resuscitation in Patients With Septic Shock
- Conditions
- Sepsis
- Registration Number
- NCT05118646
- Lead Sponsor
- Xiangya Hospital of Central South University
- Brief Summary
Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Resuscitation in Patients With Septic Shock
- Detailed Description
Objectives: Comparison of microcirculation indexes and hemodynamic indexes to guide resuscitation in patients with septic shock.
Intervention:
1. Microcirculation-oriented resuscitation group: When the system hemodynamics meets the standard of EDGT, the microcirculation-oriented resuscitation group will evaluate the organ perfusion level and adjust the hemodynamic therapy according to the sublingual microcirculation parameters (PPV \> 68%).
2. Control group: The standard treatment group will adjust the shock management scheme through systemic hemodynamic parameters.
Primary outcome:
(1)change in SOFA score at 72h (2)30-day mortality
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 62
- patients fulfilled the diagnostic criteria of septic shock.
- declined to participate
- pregnant
- patients who were younger than 18 years old
- active bleeding
- septic shock is diagnosed for more than 4 hours
- patients are expected to be die within 24hours
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method change in SOFA score 72h △SOFA
- Secondary Outcome Measures
Name Time Method 30-day mortality 30d mortality
Trial Locations
- Locations (1)
Xiangya Hospital of Central South University
🇨🇳Changsha, Hunan, China
Xiangya Hospital of Central South University🇨🇳Changsha, Hunan, ChinaLina ZhangContact