Respiratory muscle activation in COPD during noninvasive mechanical ventilatio
Not Applicable
- Conditions
- J44.89
- Registration Number
- DRKS00005639
- Lead Sponsor
- niklinik Freiburg, Department für Innere Medizin, Klinik für Pneumologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Patients with advanced stable hypercapnic COPD and established noninvasive mechanical ventilation
Exclusion Criteria
- severe hypoxia ((PaO2 < 60mmHg despite oxygen supplementation)
- haemodynamic instability within the last 24h
- neuromuscular disease
- acute infectin (procalcitonin >10 ng/ml and/or CRP > 10 mg/dl)
- missing cooperation
- use of sedative or analgetic agents within the last 6h
- body mass index > 30 kg/m2
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differences in parasternal respiratory muscle activation applying electromyography during different modes of noninvasive mechanical ventilation with respect to maximal volitional respiratory muscle activation.
- Secondary Outcome Measures
Name Time Method - resting EMG of the respiratory muscles (M. sternocleidomastoideus, parasternal muscles, diaphragm) for the right / left body side<br>- maximal innervation as assessed by EMG during maximal voluntary breathing maneuvers (PImax, Sniff, TLC-breathing)<br>- sensation of dysnpoea during different modes of noninvasive mechanical ventilation