InFLUenza and the HEART An Investigation Into the Acute and Lasting Cardiac Effects of Influenza Infection

Recruiting

• Conditions: Cardiovascular Complication; Influenza

• Registration Number: NCT05084846
• Lead Sponsor: University Hospital, Gentofte, Copenhagen

Brief Summary

"Influenza and the Heart: An investigation into the acute and lasting cardiac effects of influenza infection" the investigators aim to assess the mechanisms for cardiovascular disease in patients suffering an acute influenza infection. The project will be carried out by creating a prospective clinical cohort study of consecutive patients hospitalized at Herlev \& Gentofte University Hospital with a laboratory confirmed influenza.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-10-06
• Study First Submitted QC: 2021-10-06
• Study First Posted: 2021-10-20
• Study Start: 2022-01-01
• Status Verified: 2023-06
• Last Update Submitted: 2023-06-23
• Last Update Posted: 2023-06-26
• Primary Completion: 2024-04-01
• Study Completion: 2025-03-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• All patients hospitalized at Herlev & Gentofte University Hospital with a laboratory-confirmed diagnosis of influenza
• > 18 years of age

Exclusion Criteria

• Persons not able to cooperate
• Persons unable to understand and sign "informed consent"
• Pregnancy
• Persons simultaneously positive with COVID-19

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rate of cardiac dysfunction	3 years	Defined by impaired echocardiographic parameters and elevated cardiac biomarkers - NT; - pro; - BNP annd hs; - TNT
Number of patients developing cardiovascular complications	3 years	Including new-onset heart failure, worsening of current heart failure, acute myocardial infarction, and cardiac arrest
Number of patients developing in-hospital mortality	3 years
Prevalence of elevated biomarkers of infection/inflammation	3 years	Prevalence of elevated biomarkers of infection/inflammation and it association with cardiac dysfunction
Rate of pulmonary embolisms diagnosed with CT thorax angiography	3 years

Trial Locations

Locations (2)

Herlev & Gentofte Hospital; 🇩🇰 Copenhagen, Denmark

Cardiovascular Non-Invasive Imaging Research Laboratory, department of Cardiology, Herlev & Gentofte Hospital; 🇩🇰 Hellerup, Denmark