Study of Brain Response to Emotional Pictures Using a fMRI While on Duloxetine
- Registration Number
- NCT00532480
- Lead Sponsor
- Indiana University School of Medicine
- Brief Summary
The purpose of this study is to find out what parts of the brain have increased or decreased activity when people are depressed and how antidepressant medicine changes this activity in depressed patients. The genetic samples collected are to look at variation in a gene (serotonin transporter gene), which affects the functioning of the chemical serotonin in the brain
- Detailed Description
This study will measure the activity in different parts of the brain, while the patients are seeing some pictures, using Magnetic Resonance Imaging (MRI) scan. For this study three MRI scans will be conducted. One before the patient begins on any medication, one during the study after 3 weeks of treatment and one after six more weeks of treatment with a standard antidepressant called duloxetine.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 10
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Duolxetine Duloxetine Open-label duloxetine 30 - 60 mg oral administration
- Primary Outcome Measures
Name Time Method 17-item Hamilton Depression Rating Scale 8 weeks Standard 17-item rating scale for depression used in clinical trials. A score of 0-7 is considered to be normal. 8 - 13 mild depression. Scores of 20 or higher indicate moderate, severe, or very severe depression, and are usually required for entry into a clinical trial. Range of score: 0 - 50.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Indiana University Adult Psychiatric Clinic
🇺🇸Indianapolis, Indiana, United States