Duloxetine
- Generic Name
- Duloxetine
- Brand Names
- Cymbalta, Drizalma, Irenka, Yentreve, Duloxetine Zentiva, Duloxetine Mylan, Duloxetine Lilly
- Drug Type
- Small Molecule
- Chemical Formula
- C18H19NOS
- CAS Number
- 116539-59-4
- Unique Ingredient Identifier
- O5TNM5N07U
- Background
Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor. It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval for a variety of indications including the tre...
- Indication
Indicated for:
1) Management of Major Depressive Disorder.
2) Management of Generalized Anxiety Disorder.
3) Management of diabetic peripheral neuropathy.
4) Management of fibromyalgia.
5) Management of chronic musculoskeletal pain.
6) Management of osteoarthritis of the knee in adults.
7) Management of chronic lower back pain in adults.
...
- Associated Conditions
- Chronic Lower Back Pain (CLBP), Chronic Musculoskeletal Pain, Diabetic Peripheral Neuropathic Pain (DPN), Fibromyalgia, Generalized Anxiety Disorder, Major Depressive Disorder (MDD), Osteoarthritis of the Knee, Stress Urinary Incontinence (SUI)
- Associated Therapies
- -
Comparison of the Efficacy and Safety of Mirogabalin and Duloxetine in Chemotherapy-induced Peripheral Neuropathy in a Randomized Controlled Trial: a Quality of Life Study in Cancer Survivors
- Conditions
- Interventions
- First Posted Date
- 2024-12-02
- Last Posted Date
- 2024-12-02
- Lead Sponsor
- Pusan National University Yangsan Hospital
- Target Recruit Count
- 66
- Registration Number
- NCT06711978
- Locations
- 🇰🇷
Yangsan Pusan National University Hospital, Mulgeum, Korea, Republic of
SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.
- First Posted Date
- 2024-09-26
- Last Posted Date
- 2024-09-26
- Lead Sponsor
- University of Rochester
- Target Recruit Count
- 190
- Registration Number
- NCT06614322
- Locations
- 🇺🇸
Beth Israel Deaconess Medical Center for Autonomic and Peripheral Nerve Disorders, Boston, Massachusetts, United States
🇺🇸Washington University School of Medicine, St. Louis, Missouri, United States
🇺🇸University of Rochester, Rochester, New York, United States
Duloxetine to Prevent Chronic Postsurgical Pain After Inguinal Hernia Repair in Patients at High Risk
- Conditions
- Interventions
- First Posted Date
- 2024-09-20
- Last Posted Date
- 2024-09-20
- Lead Sponsor
- Parc de Salut Mar
- Target Recruit Count
- 294
- Registration Number
- NCT06606067
- Locations
- 🇪🇸
Hospital del Mar, Barcelona, Spain
ADC-induced Neurotoxicity Treated with Duloxetine
- First Posted Date
- 2024-08-13
- Last Posted Date
- 2024-08-13
- Lead Sponsor
- Fudan University
- Target Recruit Count
- 37
- Registration Number
- NCT06551051
- Locations
- 🇨🇳
Fudan University Cancer center, Shanghai, Shanghai, China
Evaluating the Efficacy and Safety of Preoperative Administration of Duloxetine for Pain Management in Women Undergoing Hysterectomy Via Vaginal Route
- Conditions
- Interventions
- First Posted Date
- 2024-05-28
- Last Posted Date
- 2024-07-26
- Lead Sponsor
- Erzincan Military Hospital
- Target Recruit Count
- 80
- Registration Number
- NCT06429605
- Locations
- 🇹🇷
Mugla Education and Research Hospital, Muğla, Turkey
Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty (RELIFE)
- First Posted Date
- 2024-05-21
- Last Posted Date
- 2024-05-21
- Lead Sponsor
- Sunnybrook Health Sciences Centre
- Target Recruit Count
- 150
- Registration Number
- NCT06423716
- Locations
- 🇨🇦
Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis
- Conditions
- Interventions
- First Posted Date
- 2024-02-07
- Last Posted Date
- 2024-07-24
- Lead Sponsor
- Northwestern University
- Target Recruit Count
- 180
- Registration Number
- NCT06245109
- Locations
- 🇺🇸
Northwestern University, Chicago, Illinois, United States
Patient Education and Duloxetine, Alone and in Combination, for Patients With Multisystem Functional Somatic Disorder
- Conditions
- Interventions
- First Posted Date
- 2024-01-30
- Last Posted Date
- 2024-01-30
- Lead Sponsor
- Aarhus University Hospital
- Target Recruit Count
- 424
- Registration Number
- NCT06232473
- Locations
- 🇩🇰
Research Cinic for Functional Disorders, Aarhus, Denmark
Pain Relieving Potentials of Combination of Oral Duloxetine and Intravenous Magnesium Sulphate in Post Mastectomy Pain
- Conditions
- Interventions
- First Posted Date
- 2023-10-17
- Last Posted Date
- 2023-10-17
- Lead Sponsor
- National Cancer Institute, Egypt
- Target Recruit Count
- 90
- Registration Number
- NCT06087211
- Locations
- 🇪🇬
National cancer institute, Cairo, Egypt
Duloxetine for LBP
- First Posted Date
- 2023-05-10
- Last Posted Date
- 2024-11-22
- Lead Sponsor
- Montefiore Medical Center
- Target Recruit Count
- 120
- Registration Number
- NCT05851976
- Locations
- 🇺🇸
Montefiore Medical Center, Bronx, New York, United States
Drug Development Updates
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