Cardiac Output and Cerebral Blood-flow During Carotid Endarterectomy in Regional vs. General Anesthesia. A Prospective Randomized Controlled Single Center Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 2
- 主要终点
- Influence of anesthetic technique on cardiac output during carotid endarterectomy.
研究概览
简要总结
The aim of this study is to investigate the differences between the cardiac output and the cerebral blood-flow between a regional anesthesia (RA) and a general anesthesia (GA) in a randomized, controlled, single center study at the Medical University Innsbruck, Department of Anesthesia and Intensive Care Medicine.
详细描述
The investigators will investigate the differences between the cardiac output and the cerebral blood-flow between a regional anesthesia (RA) and a general anesthesia (GA) in a randomized, controlled, single center study at the Medical University Innsbruck, Department of Anesthesia and Intensive Care Medicine.
For this purpose patients with the need of a carotid endarterectomy (CEA) will be included and randomized either to the regional anesthesia (RA) or the general anesthesia (GA) group until a patient number of 45 in each group is achieved.
The cardiac output and cerebral blood-flow via trans-cranial Doppler (TCD) will be measured at 6 time points:
- T0 Baseline (after insertion of an arterial line)
- T1 After induction of anesthesia, but before surgical start
- T2 Two minutes after clamping the carotid artery
- T3 Two minutes after shunt insertation of the carotid artery
- T4 After reperfusion
- T5 After completion of the skin suture
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age >= 18 years
- •Elective carotid endarterectomy
- •Signed informed consent
排除标准
- •Age under 18 years
- •Missing signed informed consent
结局指标
主要结局
Influence of anesthetic technique on cardiac output during carotid endarterectomy.
时间窗: Baseline to induction of anesthesia and up to 1 hour after admission to the intermediate care unit
Number of participants: 90 patients Unit of measure: Cardiac index (l/m2) Cardiac output will be measured and compared at the following time points: * T0 Baseline (after insertion of an arterial line) * T1 After induction of anesthesia, but before surgical start * T2 Two minutes after clamping the carotid artery * T3 Two minutes after shunt insertation of the carotid artery * T4 After reperfusion * T5 After completion of the skin suture
次要结局
- Influence of anesthetic technique on trans-cranial doppler flow during carotid endarterectomy.(Change of cardiac output from Baseline to induction of anesthesia and up to 1 hour after admission to the intermediate care unit)
研究者
Priv.Doz. Dr. Corinna Velik-Salchner
Priv.-Doz. Dr.
Medical University Innsbruck