Mannitol Versus Supportive Care in Ciguatera Fish Poisoning
- Registration Number
- NCT02570971
- Lead Sponsor
- University of South Florida
- Brief Summary
Ciguatera poisoning, caused by the ingestion of ciguatoxin-containing fish, is a global public health concern. In the US, the vast majority of ciguatera poisonings occur in Florida, followed by Hawaii and California. Equipoise exists in the medical literature regarding the effectiveness of mannitol therapy in treatment of ciguatera poisoning. While there are many case reports attesting to its utility, the only randomized control trial (RCT) comparing mannitol therapy with supportive care failed to show any significant benefit from mannitol treatment for a variety of clinical outcomes. Investigators therefore propose a second, larger RCT to test this question.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
- History consistent with ciguatera poisoning
- Minors
- pregnant patients
- those unable to give consent
- severe congestive heart failure or renal failure
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Investigational Mannitol Patients will receive 500mL of 20% mannitol
- Primary Outcome Measures
Name Time Method Symptom score 24 hours Covers a variety of neurological and gastrointestinal symptoms on a 0-4 score
- Secondary Outcome Measures
Name Time Method