Effects of Sildenafil on pulmonary artery pressure in patients with heart failure with preserved ejection fraction and pulmonary hypertensio
Phase 2
Completed
- Conditions
- disturbed relaxation of the heartheart failure with preserved ejection fraction10019280
- Registration Number
- NL-OMON38270
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 52
Inclusion Criteria
PH secondary to HFpEF defined as mean PAP larger 25 mmHg, wedge larger 15, LVEF larger 45
NYHA II-IV
Exclusion Criteria
other cause of PH
severe noncardiac limitation to exercise
coronary ischemia or recent myocardial infarction (<6 months)
hypotension , RR< 90/50
ongoing nitrate therapy
significant left sided valve disease
severe liver dysfunction
pregnancy
unable to read and comprehend Dutch language
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Reduction of pulmonary artery pressure (PAP) without decrease of cardiac<br /><br>output.</p><br>
- Secondary Outcome Measures
Name Time Method <p>reduction of wedge pressure<br /><br>improvement of VO2max</p><br>