Effect of Increased Intake of Low Fat Dairy Products on Weight Loss and Insulin Resistance
- Conditions
- Impaired Glucose ToleranceType 2 DiabetesMetabolic Syndrome
- Interventions
- Behavioral: High dairy and calcium intakeBehavioral: Usual intake
- Registration Number
- NCT00564551
- Lead Sponsor
- University of Calgary
- Brief Summary
The purpose of this study is to determine if increased intake of low-fat milk products and calcium as part of a calorie restricted diet helps achieve a healthier body weight and body composition and decrease blood glucose levels in people with insulin resistance or type 2 diabetes.
- Detailed Description
Obesity can cause many health problems as it is linked to several chronic diseases including type 2 diabetes. We know that individuals who are overweight or obese, and have impaired glucose tolerance or insulin resistance, have a good chance of developing type 2 diabetes. Research tells us that the risk of developing type 2 diabetes can be decreased by losing weight and making dietary changes. A promising area of study involves using low-fat milk products and calcium to prevent and/or control obesity and diabetes. This study is important because it will determine if including low-fat milk products in weight reducing diets can enhance weight loss, improve fat loss and decrease levels of blood glucose and insulin in individuals with impaired glucose tolerance or type 2 diabetes not treated with medication. This information is directly applicable to treating diseases such as obesity, type 2 diabetes and heart disease.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 49
-
Overweight and obese (BMI of 27 to 37 kg/m2)
-
Impaired glucose tolerance (fasting blood glucose >5.6 mmol/L) or
-
Type 2 diabetes treated with diet and exercise alone (no medications)
-
One or more of the following criteria for metabolic syndrome:
- Hypertriglyceridemia (> 1.70 mmol/L)
- Low high-density lipoprotein (HDL) cholesterol (< 1.04 mmol/L in men and < 1.30 mmol/L in women)
- High blood pressure (> 130/85 mm Hg)
- High waist circumference ( > 94 cm in men, > 80 cm in women)
-
Weight stable and no changes in exercise in past 3 months
- Type 1 diabetes
- Type 2 diabetes treated with oral hypoglycemic agents or insulin
- HbA1c > 8%
- myocardial infarction or have undergone a cardiovascular intervention within the past three months
- Subjects taking fibrate or statins who have had a dose change within the 8 weeks prior to randomization
- Liver or pancreas disease
- Major gastrointestinal surgeries
- Pregnant or lactating
- Exhibit alcohol or drug dependence
- Taking drugs influencing appetite
- Have a milk allergy or lactose intolerance
- Following a diet or exercise regime designed for weight loss
- Have a body weight greater than 350 lb (weight limit for DEXA instrument)
- Chronic use of bulk laxatives, antacids or calcium supplements
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 2 High dairy and calcium intake High dairy intake and calcium supplement. High intake of low-fat milk product intake (3-4 servings per day) plus one 350 mg calcium supplement per day during 500 kcal/day deficit diet. 1 Usual intake Usual diet of low dairy and calcium intake. Usual intake of low milk product intake (1 serving/day) and low calcium intake with a placebo during a 500 kcal/day deficit diet.
- Primary Outcome Measures
Name Time Method Weight loss 12 weeks
- Secondary Outcome Measures
Name Time Method Insulin and glucose response 12 weeks Inflammatory Markers 12 weeks
Trial Locations
- Locations (1)
Faculty of Kinesiology, Roger Jackson Centre for Health and Wellness Research
🇨🇦Calgary, Alberta, Canada