europhysiological Basis of Rehabilitation in Patients with Complex Regional Pain Syndrome-Type I (CRPS-I) and chronic Low Back Pain (LBP)
- Conditions
- chronic pain syndromesComplex Regional Pain Syndrome type I (CRPS-I) and chronic painchronic low back pain (LBP)
- Registration Number
- NL-OMON41326
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 75
for CRPS-I patients:
- Diagnosis of Complex Regional Pain Syndrome Type I
- Unilateral localization on upper extremity;for LBP patients:
- Experience of non-specific low back pain for at least three months
- No other diagnosis better explaining the signs and symptoms;all patients:
- Stable medication
- Substantial fear of movement/(re)-injury;for all patients and healthy controls:
- Age between 18 and 65 years old
for patients and healthy controls:
- peripheral neuropathy of upper extremity
- magnetic resonance imaging incompatible health condition
- psychopathology (according to SCL 90)
- tactile sensitivity impairment as a result of cranial, spinal lesion or damage of sensory apparatus
for healthy controls only:
- (history of) CRPS or other chronic pain syndromes
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Patients and healthy controls:<br /><br>1) Blood-oxygenation level dependent response (BOLD signal), during rest,<br /><br>during the tactile stimulations and during watching of pictures that might be<br /><br>experienced as threatful by the patients.<br /><br>2) Tactile discrimination threshold in mm (minimal offset in dot pattern<br /><br>required for reliable discrimination [>80%] of the directionality of this<br /><br>offset)(CRPS-I) / Performance on lifting task (LBP)<br /><br>3) Fractional anisotropy of water diffusivity.</p><br>
- Secondary Outcome Measures
Name Time Method