Analysis of brain protective effects of different drugs in neurosurgery

Not Applicable

Completed

• Conditions: Reduce the occurrence of postoperative complications in surgical patients; Surgery

• Registration Number: ISRCTN17014575
• Lead Sponsor: First Affiliated Hospital of Xinjiang Medical University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2020-12-30
• Study Start: 2024-06-10
• Last Update Posted: 24 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

1. Patients classified as grade II or III according to the criteria of the American Society of Anesthesiologists (ASA)
2. No restrictions on age or sex
3. Unilateral carotid artery stenosis indicated by transcranial angiography (=70% stenosis in asymptomatic patients or =50% stenosis in symptomatic patients)
4. Capable of autonomous behavior
5. Voluntarily signing an informed consent

Exclusion Criteria

1. Acute phase of cerebrovascular disease
2. Carotid artery occlusion
3. Non-visualization of distal carotid artery stenosis
4. Persistent neurological deficits
5. Long-term use of sedatives or antidepressants
6. Systemic consumptive diseases
7. Severe arrhythmias; myocardial infarction, heart failure, or poorly controlled severe hypertension
8. Severe diseases of the respiratory system

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The heart rate (HR), percutaneous cerebral oxygen saturation (SpO2), mean arterial pressure (MAP), and SrO2 are measured using the recording of data through the monitor and the recording of test results 5 min before induction of anesthesia (T0), 5 min before carotid artery clamping (T1), immediately after clamping (T2), 5 min after clamping (T3), 10 min after clamping (T4), 15 min after clamping (T5), and 15 min after the restoration of the carotid artery blood flow (T6)

Secondary Outcome Measures

Name	Time	Method
Arterial blood gas analysis and S100-ß protein detection measured using the recording of data through the monitor and the recording of test results in blood samples collected at T1, T6, and 24 h after surgery (T7)