Optimal inhalation profiles from dry powder inhalers
Not Applicable
- Conditions
- bronchial asthma chronic obstructive pulmonary disease
- Registration Number
- JPRN-UMIN000024622
- Lead Sponsor
- Department of Respiratory Medicine, Shonan Fujisawa Tokushukai Hospital
- Brief Summary
Seven asthmatics without recent deterioration and regularly inhaling Turbuhaler or Diskus. Daily inhalation profiles and particle release from either DPI were measured at home for 2 weeks. Inhalation flow profile measured at home is highly reproducible, but tends to be weaker and shorter than that measured in the laboratory. Particle release from Turbuhaler was peak flow-dependent, but that from Diskus was not. The results confirm that rapid inhalations from the start are required when using a DPI.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 1
Inclusion Criteria
Not provided
Exclusion Criteria
Those who fell into acute exacerbation at the time of study.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Amount of drug release from the dry powder inhaler in response to different inhaled flow patterns (in vitro study)
- Secondary Outcome Measures
Name Time Method Similarity of patients' inhaled flow patterns from dry powder inhalers to those from in vitro studies (in vivo study)