EFFICACY OF DEXMEDETOMIDINE VERSUS MAGNESIUM SULPHATE AND LIGNOCAINE IN LARYNGOSCOPY AND INTUBATION RESPONSE AND COMPARE THEM WITH OPIOID ANAESTHESIA

Not yet recruiting

• Conditions: Calculus of gallbladder with acutecholecystitis,

• Registration Number: CTRI/2022/01/039528
• Lead Sponsor: Akanksha Sharma

Brief Summary

AIM:

To evaluate and compare hemodynamic response and efficacy of dexmedetomidine vs magnesium sulphate and lignocaine in providing the opioid free general anaesthesia.

PRIMARY OBJECTIVE:

To compare the effect of opioid free anaesthesia with opioid based anaesthesia on hemodynamic profile during laryngoscopy and endotracheal intubation.

SECONDARY OBJECTIVES:

1. To evaluate post-operative analgesia in all groups.

2 To study post-operative nausea vomiting, sedation etc.

3. To note any other intra-operative and post-operative complication /adverse effects



Endotracheal intubation is considered a gold standard for airway management during the surgeries under general anaesthesia. Stimulation of proprioceptors at the base of the tongue during laryngoscopy induces impulse dependent tachycardia, hypertension and plasma catecholamine concentration and may be associated with sympathetic stimulation and increase in mean arterial pressure. Induction of general anaesthesia,laryngoscopy and tracheal intubation may cause acute hemodynamic instabilities. These changes in blood pressure have been associated with increased intracranial pressure,cerebral haemorrhage, myocardial ischaemia and cardiac failure.

Therefore there is need to blunt these noxious responses effectively. Opioid agents have been a mainstay for both intra and post- operative analgesia, but they are largely associated with hyperalgesia, acute tolerance, higher analgesic consumption in post-operative period, prolonged sedation, ileus, urinary retention and prolonged length of hospital stay. Moreover, the dose of opioids required for effective attenuation of stress response is fairly high.

These adverse effects of opioids are a point of concern in today’s scenario.

New approaches and today’s emphasis is on multimodal and opioid free anaesthesia with sympathetic stability to protect organs and provide sufficient tissue perfusion,analgesia and rapid emergence .With emergence of newer non opioid analgesic agents, opioid therapy could be complemented and infact replaced by the newer agents.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2022-01-19
• Study Start: 2022-03-18

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

ASA physical status I & II.

Exclusion Criteria

• Pts with H/O uncontrolled HTN or hypotension 2.
• Bradycardia 3.
• Heart blocks 4.
• Pt with Cardiovascular disease 5.
• Allergies to any studies 6.
• BMI >30 kg/m2 7.
• Pts with more than one intubation attempt 8.
• Pts who refuse to give consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
HR,SBP,DBP,MAP,SpO2,any other	Pre-infusion | Pre-induction | Baseline | 1 min | 5min | 3 min | 5 min | 7 min | 10 min | 20 min | 30 min
To compare the effect of opioid free anaesthesia with opioid based anaesthesia on hemodynamic profile	Pre-infusion | Pre-induction | Baseline | 1 min | 5min | 3 min | 5 min | 7 min | 10 min | 20 min | 30 min

Secondary Outcome Measures

Name	Time	Method
Post op vital monitoring	Post op analgesia

Trial Locations

Locations (1)

Indira Gandhi Medical College; 🇮🇳 Shimla, HIMACHAL PRADESH, India

Indira Gandhi Medical College

🇮🇳Shimla, HIMACHAL PRADESH, India

Akanksha Sharma

Principal investigator

9805633110

akanksha.kasauli@gmail.com