The estrogenic activity of phyto-estrogens in soy meassured with the ER-CALUX assay.

• Conditions: transient endocrine disruption/ hormone dysregulation; 10014701

• Registration Number: NL-OMON29807
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 6

Inclusion Criteria

- Healthy men
- Age 18 - 25
- BMI 18.5 - 25

Exclusion Criteria

- use of anti-coagulants
- diagnosis diabetes, thyroid disorder or other chronic illness that potentially involves a disturbed endocrine system
- use of hormonal medication
- chronic kidney or liver disorder
- use of antibiotics three months before the experiment
- use of meat or dairy substitutes at least two times a week for the last six months
- soy allergy
- smoking

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoint of the study is the total serum estrogenic activity<br /><br>measured with the ER-CALUX assay and expressed in estradiol equivalents (EEQs).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Information will be collected about background variables and potential<br /><br>confounders, such as age, BMI, and consumed foodstuffs and potential<br /><br>gastro-intestinal problems during the study.</p><br>