can phytoestrogens replace estradiol in reversing the antiestrogenic effect of clomid in ovulation induction in cases of Poly cystic ovarian syndrome
- Conditions
- InfertilityReproductive Health and Childbirth - Fertility including in vitro fertilisation
- Registration Number
- ACTRN12614000785606
- Lead Sponsor
- Ahmed Maged
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 150
1. All participants had the diagnosis of polycystic ovarian syndrome (PCOS) based on presence of at least two of the following diagnostic criteria should be met: oligo/anovulation; clinical signs of hyperandrogenism (e.g., hirsutism and acne) and/or biochemical measurements; or enhanced polycystic ovaries and/or multiple discrete follicles in diameter in one ovary as detected by ultrasonography. The criteria fulfilling sufficient specificity and sensitivity to define PCO are the following: `presence of 12 or more follicles in each ovary measuring 2-9 mm in diameter, and/or increased ovarian volume (>10 cm3)
2. Women with both 1ry and 2ry infertility were included.
1. women with endocrinological abnormalities as thyroid dysfunction or abnormal prolactin levels,
2. those with hypothalamic or pituitary dysfunctions evaluated by low gonadotropin level,
3. other causes of infertility as tubal factor evaluated by HSG or laparoscopy, abnormal uterine cavity evaluated by sonohystrography or hysteroscopy and male factor evaluated by semen analysis.
4. Women with ovarian cysts were also excluded from the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method clinical pregnancy at 6 weeks gestation assessed by transvaginal ultrasound[14 days after missed period]
- Secondary Outcome Measures
Name Time Method ovulation rate assessed by transvaginal ultrasound[Day 16 of cycle]