Intermittent Anti-grade Portal and Graft Purge Ameliorates Post-reperfusion Syndrome in Living Donor Liver Transplantation Recipients. A Prospective, Randomised Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hypotension
- Sponsor
- Mansoura University
- Enrollment
- 80
- Locations
- 3
- Primary Endpoint
- Post-reperfusion syndrome
- Last Updated
- 9 years ago
Overview
Brief Summary
Post-reperfusion syndrome and ischemia-reperfusion insult are a common well-known complication in liver transplantation. Several trials investigated variables that my contribute to the generation of these two complications for reducing their incidence and magnitude. The investigators will investigate the effect of acute conditioning of the recipients circulation to the vasoactive mediators in the graft as well as the congested intestine through intermittent purging of graft contents into the patient's systemic circulation in living donor liver transplantation.
Detailed Description
Patients are subjected to living donor liver transplantation. In this type of grafts, cold ischemia time is minimal and the graft contents of preservative solution are less than cadaveric grafts. The investigators in the current research use HTC as a preservative solution. These factors justified the possibility of purging the graft and portal blood contents into the patient systemic circulation. The exposure to these fluids in this trial will be in an intermittent manner: the portal vein will be declamped for 5 seconds followed by 30 seconds of portal clamping. This will be repeated twice. The primary outcome objective in this trial will be the incidence of post-reperfusion syndrome. Secondary objectives include the severity of PRS, the incidence and severity of ischemia-reperfusion injury, graft and patient's survival.
Investigators
Amr Mohamed Yassen
Professor of Anesthesia and Intensive Care
Mansoura University
Eligibility Criteria
Inclusion Criteria
- •living donor liver transplantation recipients
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Post-reperfusion syndrome
Time Frame: 5 minutes after portal declamping
Reduced Mean arterial blood pressure to the predefined value
Secondary Outcomes
- Severity of post-reperfusion syndrome(5 minutes after portal declamping)
- One month patient mortality(one month post-operative)
- Graft ischemia reperfusion injury(one week post-operative)