High Versus Standard Dose of Proton Pump Inhibitors (PPIs) in Peptic Ulcer Bleeding
- Conditions
- Peptic UlcersUpper Gastrointestinal Bleeding
- Registration Number
- NCT00374101
- Lead Sponsor
- Casa Sollievo della Sofferenza IRCCS
- Brief Summary
High intravenous dosage of Proton Pump Inhibitors is not better than standard dosage in bleeding peptic ulcers successfully treated by endoscopic therapy
- Detailed Description
The recent Canadian consensus conference on the management of patients with non-variceal upper gastrointestinal bleeding recommends a high regimen of PPIs, consisting in a dosage of 80-mg bolus followed by the 8 mg/H infusion, as being superior to the standard dosage (40 mg twice daily by bolus injection) in conjunction with some type of endoscopic therapy. However, by pooling data fromm studies comparing high doses of PPIs as continuous infusion versus regular doses as intermittent bolus, rebleeding, surgery, and mortality were not significantly different. As the previous conclusion became apparent in a meta-analytical evaluation of only 2 randomized clinical trials, more studies are needed on this topic.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 450
- Consecutive patients admitted for upper gastrointestinal bleeding secondary to peptic ulcers that have been successfully treated with endoscopic therapy
- Variceal esophageal bleeding
- Concurrent PPI use
- Moribund patients
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Rebleeding rates and surgical needs
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (4)
Division of Internal Medicine
🇮🇹Polla, Salerno, Italy
Division of Gastroenterology
🇮🇹Vasto, Italy
DIvision of Gastroenterology
🇮🇹Como, Italy
DIvision of Internal Medicine
🇮🇹Ivrea, Italy