NCT03130621Unknown不适用
Screening of Hereditary Upper Gastrointestinal Cancer in China
Peking University1 个研究点 分布在 1 个国家目标入组 500 人开始时间: 2017年1月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Pedigree analysis
研究概览
简要总结
Through exploring the specific genetic mutations in the upper gastrointestinal tract tumors with a family history and specific clinical pathological types，we establish a complete family and follow-up system，in order to improve the screening criteria of Chinese hereditary upper gastrointestinal tumors and carry on primary prevention of disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Family Based
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with gastric cancer, esophageal adenocarcinoma, or duodenal adenocarcinoma meet one of the following criteria:
- •age≤35，gastric cancer with special pathological types;
- •age≤50，≥one first-degree relative of a malignant tumor;
- •≥ two first-degree／second-degree relatives of a malignant tumor，and ≥one first-degree relative;
- •have ≥two types of malignancies，and age ≤50 at the first time of diagnosis;
- •MSI or dMMR of tissue specimen;
- •Patients with esophageal squamous cell carcinomas meet one of the following criteria:
- •≥ two first-degree／second-degree relatives of a malignant tumor，and ≥one first-degree relative;
- •have ≥two types of malignancies，and age ≤50 at the first time of diagnosis;
- •MSI or dMMR of tissue specimen;
排除标准
- •Patients do not meet one of the inclusion criteria;
结局指标
主要结局
Pedigree analysis
时间窗: In the first phase of the project, we plan to detect 40-50 families in one year. And in the second phase，we will increase the number of predigree to 200. We hope to finish the phase before 2022.3
We plan to analyse the families of patients who met the inclusion criterias through gene detection.
次要结局
- somatic mutation landscape of hereditary upper gastrointestinal cancer(We plan to accomplish sample collection, sequencing and data analysis before 2022.3)
研究者
Shen Lin
Chief physician
Peking University
研究点 (1)
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