Screening of Hereditary Upper Gastrointestinal Cancer in China

Peking University1 site in 1 country500 target enrollmentJanuary 2017

ConditionsImprove the Screening Criteria of Chinese Hereditary Upper Gastrointestinal Tumors

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Improve the Screening Criteria of Chinese Hereditary Upper Gastrointestinal Tumors
Sponsor: Peking University
Enrollment: 500
Locations: 1
Primary Endpoint: Pedigree analysis
Last Updated: 6 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Through exploring the specific genetic mutations in the upper gastrointestinal tract tumors with a family history and specific clinical pathological types，we establish a complete family and follow-up system，in order to improve the screening criteria of Chinese hereditary upper gastrointestinal tumors and carry on primary prevention of disease.

Registry

clinicaltrials.gov

Start Date

January 2017

End Date

March 2022

Last Updated

6 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Peking University

Responsible Party

Principal Investigator

Shen Lin

Chief physician

Peking University

Eligibility Criteria

Inclusion Criteria

•Patients with gastric cancer, esophageal adenocarcinoma, or duodenal adenocarcinoma meet one of the following criteria:
•age≤35，gastric cancer with special pathological types;
•age≤50，≥one first-degree relative of a malignant tumor;
•≥ two first-degree／second-degree relatives of a malignant tumor，and ≥one first-degree relative;
•have ≥two types of malignancies，and age ≤50 at the first time of diagnosis;
•MSI or dMMR of tissue specimen;
•Patients with esophageal squamous cell carcinomas meet one of the following criteria:
•≥ two first-degree／second-degree relatives of a malignant tumor，and ≥one first-degree relative;
•have ≥two types of malignancies，and age ≤50 at the first time of diagnosis;
•MSI or dMMR of tissue specimen;

Exclusion Criteria

•Patients do not meet one of the inclusion criteria;

Outcomes

Primary Outcomes

Pedigree analysis

Time Frame: In the first phase of the project, we plan to detect 40-50 families in one year. And in the second phase，we will increase the number of predigree to 200. We hope to finish the phase before 2022.3

We plan to analyse the families of patients who met the inclusion criterias through gene detection.

Secondary Outcomes

somatic mutation landscape of hereditary upper gastrointestinal cancer(We plan to accomplish sample collection, sequencing and data analysis before 2022.3)