Genetic Risk Factors for Gastrointestinal Stromal Tumors (GIST)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Gastrointestinal Stromal Tumor
- Sponsor
- Alliance for Clinical Trials in Oncology
- Enrollment
- 1
- Locations
- 1
- Primary Endpoint
- response
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
RATIONALE: Studying the genes expressed in samples of tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer.
PURPOSE: This research study is looking at tumor samples in patients undergoing treatment for gastrointestinal stromal tumors on clinical trial ACOSOG-Z9001.
Detailed Description
OBJECTIVES: Primary * To examine polymorphisms in selected genes involved in the detoxifying/metabolizing and DNA repair pathways in relation to specific mutations and types of mutation in the c-kit gene in tumor tissue from patients with gastrointestinal tumors (GIST) undergoing treatment on clinical trial ACOSOG-Z9001. Secondary * To examine approximately 758 polymorphisms among candidate genes involved in detoxification/metabolism, cell cycle control, and DNA damage/repair in relation to specific mutations and types of mutation in the c-kit gene in tumor tissue from GIST patients for hypothesis generation. (exploratory) * To conduct an exploratory analysis of the polymorphism distribution in these patients. (exploratory) * To examine the association between the above polymorphisms and major toxicity (Grade 3/4) of adjuvant imatinib mesylate. (exploratory) OUTLINE: Tumor samples are used for polymorphism and mutation analysis.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
response
Time Frame: Up to 5 years