Genetic Study of Familial Factors in Patients With Colon Cancer

Completed

• Conditions: Colorectal Cancer

• Registration Number: NCT00055848
• Lead Sponsor: Alliance for Clinical Trials in Oncology

Brief Summary

RATIONALE: Genetic studies may help in understanding the genetic processes involved in the development of some types of cancer.

PURPOSE: Clinical trial to study the cancer-related genes in patients who have colon cancer or adenomatous polyps.

Detailed Description

OBJECTIVES:

* Identify human colon neoplasia susceptibility genes in patients with colon cancer or adenomatous polyps.

* Correlate the inheritance of novel susceptibility alleles for adenomatous polyposis of the colon with colon neoplasia in these patients.

* Correlate colon neoplasia susceptibility with the presence of COX-2, sPLA2, and DNMT genes in these patients.

* Identify a novel gene that governs increased susceptibility to colon adenoma and cancer in the genome of these patients.

Study Timeline

• Study Start: 2001-12
• Study First Submitted: 2003-03-06
• Study First Submitted QC: 2003-03-06
• Study First Posted: 2003-03-07
• Primary Completion: 2010-10
• Study Completion: 2010-10
• Status Verified: 2015-07
• Last Update Submitted: 2016-07-12
• Last Update Posted: 2016-07-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Wayne Memorial Hospital, Incorporated; 🇺🇸 Goldsboro, North Carolina, United States