Clinical and Laboratory Analysis of Familial Cancer

Background:

DNA makes up the instruction book for people s cells. Cancer is a disease caused by DNA changes that build up and affect cell function. Researchers want to learn more about what may cause cancer by testing the DNA of people with the disease and their family members.

Objective:

To find DNA changes that may be inherited and may cause or influence whether a person gets cancer. To study families with clusters of cancer to find out if there is a DNA mutation specific to certain cancers.

Eligibility:

People 18 years of age and older who:

Participated in the familial genetic part of NIH study 09-C-0079, a previous study or had family members enrolled in this study

Design:

Participants may have been screened in the previous study. They will give permission for researchers to use their data and their tissue or blood samples collected in the study.

Participants may give blood samples.

At each stage of testing, participants will meet with a genetics health care provider. The provider will explain the tests and answer questions.

If researchers find a DNA change that might increase the risk for cancer or other health issues, they will confirm this result in a testing lab. This will require a blood sample.

Participants personal DNA data and health information will be put in a database for research purposes.