Effects of cTBS at left and right insula using deep TMS on cue-induced nicotine craving and cognitive control

• Conditions: smoking addiction; Tobacco use disorder; 10037176

• Registration Number: NL-OMON56171
• Lead Sponsor: Amsterdam UMC

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 54

Inclusion Criteria

Age of 18-30 year
Females: use of a medically accepted form of hormonal birth control
Smoking on average at least 10 filter cigarettes per day
Smoking for at least one year
Primarily smoking filter cigarettes and not any other form of tobacco

Exclusion Criteria

Previous experience with (deep) rTMS
No reliable communication with the investigator or coping with the requirements
of the experiment possible
Last year or current psychiatric disorder diagnosis or treatment
Suffering from a neurological disorder
Possible alcohol dependence or drug (other than tobacco) use disorder diagnosis
TMS contraindications

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Subjective cue-induced nicotine craving, measured by the Questionnaire on<br /><br>Smoking Urges score after a smoking cue-exposure task, and behavioural<br /><br>cognitive control, measured by the stop signal reaction time on the stop signal<br /><br>task.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Physiological cue-induced nicotine craving and cognitive control, measured by<br />heart rate variability and skin conductance level.</p>