Substituted Frozen Embryo Transfer Cycles With GnRH-agonist Supplementation
Phase 4
Completed
- Conditions
- Pregnancy LossFrozen Embryo Transfer
- Interventions
- Registration Number
- NCT01943812
- Lead Sponsor
- Peter Humaidan
- Brief Summary
The aim of this study is to compare two FET protocols by modifying the substituted FET cycle in order to maintain a higher ongoing positive pregnancy rate and thus reduce the early pregnancy loss.
Hypothesis: adding GnRH-agonist to the substituted cycle in FET treatment reduces the early pregnancy loss.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 287
Inclusion Criteria
- Endometrial thickness ≥ 7 mm after stimulation
- 18-45 years
- IVF/ICSI fertilisation
- BMI > 18,5 <30 kg/m2
- cycle length 25-34 days
Exclusion Criteria
- endometrial thickness < 7 mm or no triple layer endometrium and/or functional follicles
- Uterine abnormality
- Chronic medical disease
- oocyte donation cycles
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Substituted FET cycle and GnRHa Estradiol and progeterone Substituted FET GnRH-a 2 bolus two days before Estradiol 6 mg Progesterone (Crinone) 180 mg Substituted FET cycle Estradiol and progeterone substituted FET cycle Estradiol Progesterone
- Primary Outcome Measures
Name Time Method Pregnancy loss rate Primary outcome is avaible after 12th week of gestational.
- Secondary Outcome Measures
Name Time Method Pregnancy rate 14 days after embryo transfer.
Trial Locations
- Locations (2)
IVF syd
🇩🇰Fredericia, Denmark
Fertility Clinic Regional Hospital Skive
🇩🇰Skive, Denmark