Effects of the Cornelian Cherry (Cornus Mas L.) Lyophilisate Supplementation on the Selected Physiological Parameters in Amateur Long-Distance Runners
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Systemic vascular resistance
研究概览
简要总结
Growing body of evidence indicates favorable effects of Cornus mas (Cornelian cherry) supplements on cardiometabolic risk, including the improvement of HDL and glycemic indices, in line with vascular benefits. Experimental data feature bioactives from Cornelian cherry as potential modulators of vascular function and blood pressure, plausibly via endothelial nitric oxide-related pathways, with possible downstream effects on autonomic reflex control; nevertheless, such links in humans remain poorly explored to date, especially in terms of endurance training and hypoxia tolerance.
In this cross-over, placebo-controlled study, a group of healthy amateur long-distance runners underwent two stages of a four-week dietary intervention (separated by four weeks of washout period), receiving Cornelian cherry lyophilisate or placebo. Each supplementation stage was accompanied by the comprehensive evaluation of the cardio-respiratory parameters and endothelial function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 45 Years 至 75 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •age above 45 years
排除标准
- •chronic disease of the nervous, cardiovascular or respiratory system
- •disease of the digestive system, including history of the intestinal surgery, inflammatory bowel disease, celiac disease, lactose intolerance and other malabsorption disorders
- •blood pressure-lowering treatment within the past year
- •tobacco smoking within the past year
- •antibiotic/probiotic treatment and laxative/prokinetic usage in three months preceding the anticipated enrollment
结局指标
主要结局
Systemic vascular resistance
时间窗: From the beginning to the end of a supplementation period at 4 weeks.
Resting systemic vascular resistance, evaluated non-invasively with a finger cuff-based device.
Office blood pressure values (mean, systolic, diastolic)
时间窗: From the beginning to the end of a supplementation period at 4 weeks.
Resting arterial blood pressure values (mean, systolic, diastolic), measured continuously with a non-invasive, finger cuff-based device.
次要结局
- Peripheral chemoreflex sensitivity(From the beginning to the end of a supplementation period at 4 weeks.)
- eNOS expression(From the beginning to the end of a supplementation period at 4 weeks.)
研究者
Rafał Seredyński
Principal Investigator
Wroclaw Medical University