Influence of Tart Cherry Juice Intervention on Vascular Function and the Urinary Metabolite; a Preliminary Study to Inform Study Design
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Dietary Exposure
- Sponsor
- Northumbria University
- Enrollment
- 23
- Locations
- 1
- Primary Endpoint
- Systolic and diastolic blood pressure
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Diets containing fruit rich in anthocyanins have been shown (in meta-analyses) to be beneficial for health, but intervention trials have shown inconsistent results. In this preliminary study we want to investigate the influence of a tart-cherry juice intervention on vascular function and explore metabolite profiles that may offer insight into their mechanism of action
Detailed Description
Cardiovascular disease (CVD) is the primary cause of morbidity and mortality. Tart cherries (TC) can positively impact major risk factors of CVD, activities thought to be related to their phytochemical content. However, data from human trials is less clear. TC have been shown to reduce systolic blood pressure (SBP) after acute, short-term and chronic intake, and to improve vascular dysfunction, presumably due to their antioxidant and anti-inflammatory activities. Other studies have not shown benefits of TC on SBP or vascular function and studies are difficult to interpret with different populations, dosing and durations being used as well as a lack of understanding for any underlying mechanisms. To account for the latter, the use of metabolomics has become increasingly popular in nutritional research. Therefore, the aim of this preliminary study was to characterise the effects of TC supplementation on vascular function with a 4-week intervention and explore if metabolomics can provide mechanistic evidence and this will inform for future chronic studies with TC juice.
Investigators
Eligibility Criteria
Inclusion Criteria
- •aged 19-40
- •no diagnosed issues with the ability to consume fruit juice
- •no known food intolerances to fruits
Exclusion Criteria
- •participants that are cigarette smokers
- •participants diagnosed with hypertension
- •participants diagnosed with any form of cardiometabolic diseases
- •participants that require any prescribed prescriptions excluding the contraceptive pill
- •participants that are regular consumers of cherries (\>100 g/d)
- •participants that consume any antioxidant supplements
Outcomes
Primary Outcomes
Systolic and diastolic blood pressure
Time Frame: Change in blood pressure following 4 weeks intervention
Measurement of systolic and diastolic blood pressure before and after the intervention
Arterial pulse wave velocity
Time Frame: Change in pulse wave velocity following 4 weeks intervention
Measurement of pulse wave velocity before and after the intervention
Digital volume pulse
Time Frame: Change in digital volume pulse following 4 weeks intervention
Measurement of digital volume pulse before and after the intervention
Secondary Outcomes
- Metabolomics(Changes to urinary metabolite profiles following 4 weeks intervention)