Refractory Urge Incontinence in Women: a randomized placebo controlled trial of antibiotic therapy for cystitis erradicatio

Phase 4

Recruiting

• Conditions: detrusor overactivity; urge incontinence; bacterial cystitis; Renal and Urogenital - Other renal and urogenital disorders; Infection - Studies of infection and infectious agents

• Registration Number: ACTRN12613000285752
• Lead Sponsor: niversity of New South Wales

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-03-11
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 166

Inclusion Criteria

Patients will be female, over 50 years of age who present with a main complaint of urge incontinence.
Urodynamic testing will show a primary diagnosis of detrusor overactivity (DO).
Patients will have failed to respond to bladder training with at least 2 anti-muscarinic therapeutic agents over 2 years.
Participants must leak urine at least 1 episode per 3 days on frequency volume chart.

Exclusion Criteria

a. Neuropathic DO (such as multiple sclerosis, spinal cord injury, Parkinsonism) b. Voiding dysfunction, defined as urinary flow rate less than 15 ml per sec for volume greater than 200ml with residual volume greater than 100ml c. Insufficient English language skills, or dementia, ie unable to complete questionnaires unaided. d. elevated creatinine, renal failure, e. allergy to more than penicillin

Study & Design

• Study Type: Interventional
• Study Design: Not specified