eurocognitive effects of low-grade glioma resection in eloquent areas
Recruiting
- Conditions
- brain tumorlow-grade glioma1002921110019190
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
Neuropsychological study:
- Untreated or recurrent lesion in or near eloquent brain areas
- At preoperative diagnosis: presumed low grade glioma
- 18-65 years old
- Fluent in speaking and understanding the Dutch language
Exclusion Criteria
- History of a medical, neurological or psychiatric condition known to affect cognitive
functioning
- (History of) substance abuse
- Suffering from permanent cognitive or motor problems caused by previous surgery
- Risk factors for awake surgery
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1) The change and recovery in performance in the main neuropsychological<br /><br>domains (language, memory, attention, executive functions, visuoconstruction,<br /><br>praxis) as measured with standardized neuropsychological tests.<br /><br>2) Change in perceived quality of life, as measured with QoL questionnaires.</p><br>
- Secondary Outcome Measures
Name Time Method <p>For the neuropsychological study:<br /><br>1) The influence of tumor characteristics (localization, histological type,<br /><br>pathological grade (WHO) and volume).<br /><br>2) The influence of the extent of the resection.<br /><br>3) The influence of (type and dose of) antiepileptic medication.<br /><br>4) The influence of (type and dose of) postsurgical treatment, with either<br /><br>radiotherapy, chemotherapy, or both. </p><br>