TCTR20220802003已完成2 期
Changes in plasma metabolomes & effects of ONS in thalassemia with malnutrition
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 100
研究概览
简要总结
The prevalence of malnutrition in adult thalassemia was 20%. Plasma metabolomic profile suggested that the malnourished thalassemia had imbalanced proteolysis and deregulation of acylcarnitine derivatives that were associated with decreased fatty acid oxidation. ONS improved nutritional status and fatty acid oxidation in malnourished thalassemia.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 60 Years（—）
- 性别
- All
入选标准
- •1. Thalassemia patient diagnosed by HPLC method
- •2. Accept to enrollment and give an inform consent
排除标准
- •1. Inherited metabolic disorders
- •2. Liver disease
- •3. Renal parenchymal disease (eGFR < 60)
- •4. Other hemolytic anemia
- •5. Multiple myeloma
- •6. Malignancy
- •7. Active infection
- •8. Chronic alcohol drinking
研究者
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