TCTR20220802003
已完成
2 期
Changes in plasma metabolomes & effects of ONS in thalassemia with malnutrition
概览
- 阶段
- 2 期
- 干预措施
- 未指定
- 疾病 / 适应症
- Metabolomic in thalassemia with manutrition
- 发起方
- Faculty of Medicine, Chiang Mai University
- 入组人数
- 100
- 状态
- 已完成
- 最后更新
- 去年
概览
简要总结
The prevalence of malnutrition in adult thalassemia was 20%. Plasma metabolomic profile suggested that the malnourished thalassemia had imbalanced proteolysis and deregulation of acylcarnitine derivatives that were associated with decreased fatty acid oxidation. ONS improved nutritional status and fatty acid oxidation in malnourished thalassemia.
研究者
入排标准
入选标准
- •1\. Thalassemia patient diagnosed by HPLC method
- •2\. Accept to enrollment and give an inform consent
排除标准
- •1\. Inherited metabolic disorders
- •2\. Liver disease
- •3\. Renal parenchymal disease (eGFR \< 60\)
- •4\. Other hemolytic anemia
- •5\. Multiple myeloma
- •6\. Malignancy
- •7\. Active infection
- •8\. Chronic alcohol drinking
结局指标
主要结局
未指定
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