Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot Study
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 13
- 试验地点
- 2
- 主要终点
- Corneal Imaging
研究概览
简要总结
The aim of the present study is to develop a protocol for optimal corneal 3-dimensional imaging based on measurements in healthy volunteers. For this purpose, a customized ultra-high resolution Spectral Domain OCT will be used. To validate whether the protocol can also be applied in patients with corneal pathologies, for whom it is intended to be used, measurements in these patients will be performed. We propose to obtain images from patients with keratoconus, since this is one of the most frequent causes for corneal transplantations in Europe and from patients with corneal neovascularization which is a major cause of vision loss in several ophthalmic diseases. Based on the obtained measurement protocol, further studies investigating the pathophysiology or treatment success of several corneal pathologies can be planned.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers:
- •Men and women aged over 18 years
- •Normal findings in the slit lamp examination, no corneal pathologies
- •Patients with keratoconus:
- •Men and women aged over 18 years
- •Presence of keratoconus
- •No ophthalmic surgery in the 3 months preceding the study
- •Patients with corneal neovascularization:
- •Men and women aged over 18 years
- •Presence of corneal neovascularization
- •No ophthalmic surgery in the 3 months preceding the study
排除标准
- •Participation in a clinical trial in the previous 3 weeks
- •Presence of any abnormalities preventing reliable measurements as judged by the investigator
- •Pregnancy, planned pregnancy or lactating
结局指标
主要结局
Corneal Imaging
时间窗: 1 day
Development of a measurement protocol for 3 dimensional imaging of the human cornea
次要结局
- Imaging of corneal pathologies(1 day)
研究者
Gerhard Garhofer
Assoc. Prof. PD Dr.
Medical University of Vienna