Role and Mechanism of PyroEVs in Regulating Lipid Droplet-Mitochondrial Coupling Via PLIN3 in Sepsis-Induced Vascular Endothelial Cell Injury
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Concentration of pyroptic extracellular vesicles (PyroEVs) in plasma
研究概览
简要总结
Objective: To investigate the correlation of PyroEVs and PLIN3 with the severity and prognosis of sepsis patients.
Participants: Sepsis patients meeting the Sepsis 3.0 diagnostic criteria admitted to the Intensive Care Unit of Zhongda Hospital affiliated with Southeast University, as well as healthy volunteers.
Inclusion Criteria:
- Presence of confirmed or suspected infection;
- Sequential Organ Failure Assessment (SOFA) score increase ≥ 2 points from baseline;
- Signed informed consent. Exclusion Criteria: Age < 18 or > 80 years, pregnancy, cancer patients, and individuals with diseases potentially complicated by vascular endothelial cell injury.
Primary outcome: 28-day mortality, SOFA score
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •a. Presence of confirmed or suspected infection; b. Sequential Organ Failure Assessment (SOFA) score increase ≥ 2 points from baseline; c. Signed informed consent.
排除标准
- •Age < 18 or > 80 years, pregnancy, cancer patients, and individuals with diseases potentially complicated by vascular endothelial cell injury.
结局指标
主要结局
Concentration of pyroptic extracellular vesicles (PyroEVs) in plasma
时间窗: Day 1
The concentration of pyroptic extracellular vesicles (PyroEVs) in plasma will be measured using nanoparticle tracking analysis. Results will be reported as particles per milliliter (particles/mL).
Concentration of PLIN3 in plasma
时间窗: Day 1
28-day mortality
时间窗: 28 days
SOFA score
时间窗: 28 days
次要结局
未报告次要终点
研究者
Fei Peng
Principal Investigator
Zhongda Hospital