Effects of Heart Rate Oscillations During Meditation on Plasma Biomarkers of Alzheimer's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 94
- 试验地点
- 1
- 主要终点
- Change in Plasma Amyloid Beta (Aβ) Levels
研究概览
简要总结
In the current study, we will examine how two types of concentration meditation practices affect plasma biomarkers of Alzheimer's Disease (AD). We will also examine the effects of the two types of meditation practices on emotional well-being and episodic memory. Healthy adults aged 18-35 who meet all eligibility criteria will be invited to this study. Participants will be asked to engage in one week of daily meditation practice or no-intervention control task at home. They will also be asked to visit the lab twice, once before and once after the intervention, to provide blood samples to assess plasma biomarkers of AD and to complete emotion questionnaires and a memory test.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Fluent in English
- •Aged between 18-35 years old
- •Agree to provide blood samples
- •Healthy adults who weigh at least 110 pounds
- •Agree to devote 40 minutes daily to this study for a week
排除标准
- •Have a disorder that would affect heart rhythm or function (e.g., abnormal cardiac rhythm, dyspnea, heart disease including coronary artery disease, angina and arrhythmia)
- •Regularly practicing any relaxation, meditation or yoga that involve breathing focused practices lasting for more than an hour each week
结局指标
主要结局
Change in Plasma Amyloid Beta (Aβ) Levels
时间窗: Measured from blood draws before and after a one-week intervention
The investigators computed an aggregate Z-score based on plasma Aβ40 and Aβ42 levels (pg/mL). A Z-score of 0 represents the sample mean. Higher values indicate a greater level of plasma Aβ, which in cognitively normal individuals has been found to be associated with a higher risk of converting to Alzheimer's disease (Song et al., 2011). They conducted a 2 (time: pre, post) × 3 (condition) ANOVA to test for a time × condition interaction in plasma Aβ levels, assessing group differences in change over time.
Change in Plasma Ab42/40 Ratio
时间窗: Measured from blood draws before and after a one-week intervention
The investigators conducted a 2 (time: pre, post) × 3 (condition) ANOVA to test for an interaction effect on plasma Ab42/40 ratios. The plasma Ab42/40 ratio was calculated by dividing the plasma Ab42 concentration (pg/ml) by the plasma Ab40 concentration (pg/ml). A higher plasma Ab42/40 ratio indicates better outcome (i.e., greater brain clearance).
次要结局
- Change in Plasma pTau-181/Tau Ratio(Measured from blood draws before and after a one-week intervention)
- Change in Emotional Well-being(Measured before and after a one-week intervention)
研究者
Mara Mather
Professor
University of Southern California