Immunoprotecting effects of aerobic and resistance exercises against ovarian cancer

Not Applicable

Completed

• Conditions: Neoplasms

• Registration Number: KCT0007468
• Lead Sponsor: Seoul Songdo Hospital

Brief Summary

Exercise is known to help the immune function of cancer survivors after cancer cell removal, but there is little information about the effect of exercise on ovarian cancer patients. We conducted this study to investigate the effects of exercise training on the physical fitness and innate immunity of ovarian cancer survivors (OCS). Twenty-seven OCS between 42 and 61 years of age volunteered for this study. The participants were divided into a control group (COG, n = 15) and an exercise group (EXG, n = 12). The mean (SD) age was 51.07 (5.67) years, and the mean post-operation period was 45.96 (5.88) months. EXG participated in regular exercise training 6 days a week for 12 weeks. Body weight, fat mass, and body mass index of EXE were significantly decreased compared with those of COG. The muscle mass in EXE was increased compared to that of COG. Physical fitness factors showed positive changes in EXG compared to COG. We found that exercise training enhanced lymphocyte and neutrophil counts of leucocytes and total natural killer (NK) and natural killer T (NKT) cell counts of lymphocytes through improved body composition and physical fitness after 12 weeks. Moreover, we found that improved innate immune cells through exercise were achieved through an increase in NKG2D+NK receptors and a decrease in KIR2DL3+NK receptors in OCS.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2021-12-24
• Last Update Posted: 20 September 2022

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 27

Inclusion Criteria

Ovarian cancer survivor who underwent interval debulking surgery, primary cytoreductive surgery, radiation therapy, or chemotherapy with a survival rate of less than 5 years. Considering the purpose of this study, survivors were subjected to continuous nutritional management at the hospital, but only subjects who had no experience participating in a regular exercise program.

Exclusion Criteria

Subjects who had severe arthritis, obesity, psychiatric illness, uncontrolled hypertension, or problems with a major organ system that could interfere with exercise were excluded from the study.

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
K cell-related factors, body composition, physical fitness

Secondary Outcome Measures

Name	Time	Method
Daily calorie intake, daily activity