Effects of Resistance Exercise on Physical Fitness, Innate Immunocytes and Adaptive Immunocytes in Cancer Survivors
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 27
研究概览
简要总结
Exercise is known to help the immune function of cancer survivors after cancer cell removal, but there is little information about the effect of exercise on ovarian cancer patients. We conducted this study to investigate the effects of exercise training on the physical fitness and innate immunity of ovarian cancer survivors (OCS). Twenty-seven OCS between 42 and 61 years of age volunteered for this study. The participants were divided into a control group (COG, n = 15) and an exercise group (EXG, n = 12). The mean (SD) age was 51.07 (5.67) years, and the mean post-operation period was 45.96 (5.88) months. EXG participated in regular exercise training 6 days a week for 12 weeks. Body weight, fat mass, and body mass index of EXE were significantly decreased compared with those of COG. The muscle mass in EXE was increased compared to that of COG. Physical fitness factors showed positive changes in EXG compared to COG. We found that exercise training enhanced lymphocyte and neutrophil counts of leucocytes and total natural killer (NK) and natural killer T (NKT) cell counts of lymphocytes through improved body composition and physical fitness after 12 weeks. Moreover, we found that improved innate immune cells through exercise were achieved through an increase in NKG2D+NK receptors and a decrease in KIR2DL3+NK receptors in OCS.
研究设计
- 研究类型
- Interventional Study
入排标准
- 年龄范围
- 42(Year) 至 61(Year)（—）
- 性别
- Female
入选标准
- •Ovarian cancer survivor who underwent interval debulking surgery, primary cytoreductive surgery, radiation therapy, or chemotherapy with a survival rate of less than 5 years. Considering the purpose of this study, survivors were subjected to continuous nutritional management at the hospital, but only subjects who had no experience participating in a regular exercise program.
排除标准
- •Subjects who had severe arthritis, obesity, psychiatric illness, uncontrolled hypertension, or problems with a major organ system that could interfere with exercise were excluded from the study.