Role of Testosterone in Prevention of Alzheimer’s Disease

Not Applicable

Completed

• Conditions: Neurological - Dementias; Prevention of Alzheimer's disease

• Registration Number: ACTRN12614000277640
• Lead Sponsor: McCusker Alzheimer's Research Foundation

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-03-17
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 44

Inclusion Criteria

Male participants: needed to 1) be 50 years of age or older, and have 2) a memory complaint, 3) testosterone levels between 300-600 ng/dL (~10.4 - 20.8 nmol/L), 4) normal levels of PSA, 5) blood pressure within normal limits, 6) no signs of diabetes mellitus, 7) normal liver and kidney enzyme function, and 8) No history of major head injury.

The diagnosis of subjective memory loss (complaint of memory loss but not meeting the criteria for dementia) was reached after a full clinical evaluation including a review of medical and drug history and a physical examination.

Exclusion Criteria

Any participants meeting the criteria for Dementia were excluded from the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cognition: Neuropsychological Tests/Questionnaires: <br>1. MMSE<br>2. Rey Auditory Verbal Learning Test<br>3. Short form 36 questionnaire<br>4. Geriatric Depression Scale<br>5. Depression, Anxiety and Stress Scales [Assessed during the following different time points :<br>1) assessed at baseline <br>2) assessed at week-8, week-16 and week-24 of the treatment period <br>3) assessed at the end of washout period (week-28) <br>4) assessed similarly in the cross-over period (week 28-52)]