A Randomized Controlled Trial of Computer-Driven Weaning Compared With Standard of Care Weaning in Medical Patients Requiring Mechanical Ventilation
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- Duration of Weaning
研究概览
简要总结
The purpose of this study is to compare the efficacy of a computer-assisted ventilator weaning system (Drager Smartcare) to our current standard of care in the medical intensive care unit.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age greater than 18 years
- •Initiated on mechanical ventilation via endotracheal tube
- •Admitted to Medical Intensive Care Unit and Medical Intensive Care Unit Team (Harrison Avenue Campus, Menino Pavilion)
- •Requiring mechanical ventilation for more than 48 hours
- •Meets prespecified weaning criteria
排除标准
- •Do Not Resuscitate/Do Not Intubate order
- •Pregnancy
- •Mechanical ventilation initiated at another hospital
- •Cardiac arrest for more than 5 minutes with poor neurologic prognosis
- •Tracheostomy
研究组 & 干预措施
Computer-assisted weaning
Group assigned to the computer-assisted weaning program
干预措施: Computer-assisted weaning program (Device)
Standard of care weaning
Group assigned to receive current, evidence-based, standard of care for discontinuation of mechanical ventilation.
干预措施: Standard of Care weaning (Behavioral)
结局指标
主要结局
Duration of Weaning
时间窗: Continuous (median weaning duration was 2 days)
Duration of weaning was assessed as the time from the initiation of weaning (randomization) to the time of successful extubation (defined as 48 hours free of mechanical ventilation). Patients were followed for the duration of hospitalization and the time of weaning onset and successful liberation from the ventilator was noted.
次要结局
- Duration of Hospitalization(from start of weaning to discharge from hospital, on average 1-2 weeks)
- Inpatient Mortality(28 days)
- Sedation Requirements(during weaning, on average 1-2 days)
- Number of Spontaneous Breathing Trials Prior to Extubation(from start of weaning to liberation from ventilator, on average 1-2 days)
- Complications (Death During Wean, Ventilator-associated Pneumonia During Wean, Self Extubation, Re-intubation)(Duration of weaning (median 2 days))
- Duration of ICU Stay(from start of weaning to discharge from ICU, on average 1-2 weeks)
- Duration of Mechanical Ventilation(from start of weaning to liberation from ventilator, on average 1-2 days)