Garlic Oil As Root Filling Material in Primary Molars

Not Applicable

Not yet recruiting

• Conditions: Irreversible Pulpitis (toothache)
• Interventions: Combination Product: Garlic oil; Drug: Calcium Hydroxide, Iodoform, paste

• Registration Number: NCT06755502
• Lead Sponsor: Cairo University

Brief Summary

The goal of this study is to test garlic oil mixed with zinc oxide as a potential root canal filling material of primary molars in children aged from four to eight years.

the study hypothesized that garlic oil mixed with zinc oxide would be the same as the gold standard filling material (metapex).

The group receiving the garlic oil with zinc oxide as root canal filling material will be compared with other similar group receiving metapex as root canal filling material in terms of clinical and radio-graphic success, and working time.

Detailed Description

This study is a randomized clinical trial (RCT), that aims compare the clinical and radio-graphic success of garlic oil mixed with zinc oxide, used as root canal filling material in primary molars in children aged from four to eight years, with the conventional root filling material, which is metapex.

Study Timeline

• Study First Submitted: 2024-12-25
• Study First Submitted QC: 2024-12-25
• Study First Posted: 2025-01-01
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-18
• Last Update Posted: 2025-03-20
• Study Start: 2025-08-08
• Primary Completion: 2026-10-08
• Study Completion: 2026-11-08

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Primary second molars which are diagnosed with irreversible pulpitis, or pulp necrosis.
2. Presence of sinus tract.
3. Periapical bone swelling.
4. Continuous bleeding after amputation of the coronal pulp tissue.
5. No pulp tissue remains when the pulp chamber is accessed.
6. Pus discharges from the canal.
7. Radiographically, only primary molars with at least two-thirds of the root length.
8. Presence of inter-radicular or periapical radiolucency.

Exclusion Criteria

1. A tooth with internal root resorption will not be included. 2. Excessive tooth mobility beyond healing. 3. Carious perforation in the pulpal flour. 4. A tooth with a pathological lesion extending to the successor's tooth germ. 5. Non-restorable primary molars.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
garlic oil with zinc oxide group	Garlic oil	-
metapex group	Calcium Hydroxide, Iodoform, paste	-

Primary Outcome Measures

Name	Time	Method
The clinical success rate	3, 6,9,and 12 months	The criteria of successful treatment, according to which the clinical evaluation will be done, will be "No abnormal mobility", "No sensitivity to percussion", and "No swelling"
Radio-graphic success	6, and 12 month.	For the radiographic success, the evaluation criteria will be "Preoperative pathological inter-radicular and/or periapical radiolucency started to resolve, or remained the same size", "No new postoperative pathological radiolucency developed", and "No pathological internal or external root resorption"