Overview
Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast.
Background
Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast.
Indication
Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. It is vital in cell signaling, muscular contractions, bone health, and signalling cascades.
Associated Conditions
- Calcium Deficiency
- Deficiency, Vitamin D
- Osteodystrophy
- Osteomalacia
- Osteoporosis
- Chronic Hypocalcemia
- Chronic Hypocalcemia caused by anticonvulsant medications
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2025/06/11 | Phase 2 | Not yet recruiting | Juno Therapeutics, Inc., a Bristol-Myers Squibb Company | ||
2025/04/16 | Not Applicable | Recruiting | Samuel Lunenfeld Research Institute, Mount Sinai Hospital | ||
2025/02/12 | Phase 2 | Not yet recruiting | Komal Ashraf Khan | ||
2025/02/04 | Phase 4 | Completed | |||
2025/01/16 | Not Applicable | Completed | |||
2025/01/08 | Not Applicable | Not yet recruiting | |||
2025/01/01 | Not Applicable | Not yet recruiting | |||
2024/11/27 | Phase 2 | Completed | District Headquarters Teaching Hospital Sahiwal | ||
2024/11/25 | Phase 1 | Recruiting | |||
2024/11/12 | Phase 4 | Not yet recruiting |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Avion Pharmaceuticals, LLC | 75854-313 | ORAL | 155 mg in 1 1 | 1/7/2021 | |
| Avion Pharmaceuticals, LLC | 75854-312 | ORAL | 155 mg in 1 1 | 1/7/2021 | |
| PruGen, Inc. Pharmaceuticals | 42546-300 | ORAL | 124.1 mg in 1 1 | 2/22/2013 | |
| Acella Pharmaceuticals, LLC | 42192-321 | ORAL | 140 mg in 1 1 | 1/5/2018 | |
| METHOD PHARMACEUTICALS, LLC | 58657-170 | ORAL | 200 mg in 1 1 | 12/10/2023 | |
| Avion Pharmaceuticals, LLC | 75854-314 | ORAL | 155 mg in 1 1 | 1/7/2021 | |
| Pharmics, Inc. | 0813-0202 | ORAL | 200 mg in 1 1 | 9/6/2012 | |
| Bryant Ranch Prepack | 63629-3545 | ORAL | 200 mg in 1 1 | 7/17/2014 | |
| Exeltis USA, Inc. | 0642-0079 | ORAL | 100 mg in 1 1 | 12/31/2022 | |
| Acella Pharmaceuticals, LLC | 42192-323 | ORAL | 160 mg in 1 1 | 9/11/2018 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| LEUCOVORIN CALCIUM folinic acid (as calcium folinate) 100mg/10mL injection USP | 49312 | Medicine | A | 6/23/1994 | |
| DBL LEUCOVORIN CALCIUM folinic acid 15 mg/2mL (as calcium folinate) injection ampoule | 16351 | Medicine | A | 10/8/1991 | |
| CALCIUM FOLINATE EBEWE folinic acid (as calcium folinate) 1000 mg/100 mL injection vial | 166260 | Medicine | A | 2/14/2011 | |
| InNatal | 346421 | Medicine | A | 10/22/2020 | |
| Adrenal Adapt | 444375 | Medicine | A | 3/25/2024 | |
| ORGANIC Iron COMPLETE | 372450 | Medicine | A | 8/9/2021 | |
| Natal Care | 395834 | Medicine | A | 9/12/2022 | |
| Ultra Nature Selancy Men | 407238 | Selima Pharmaceuticals | Medicine | A | 4/3/2023 |
| Leucovorin Calcium Injection 50 mg/5 mL (8) | 406772 | Medicine | A | 3/24/2023 | |
| Snapshot Activated Folate | 484112 | Medicine | A | 3/26/2025 |