Short-Term Effects of Antihypertensive Drugs on Postural Balance and Fall Risk
- Conditions
- HypertensionFall RiskPostural BalanceFear of Falling
- Interventions
- Registration Number
- NCT07099677
- Lead Sponsor
- Abant Izzet Baysal University
- Brief Summary
The goal of this clinical trial is to compare the short-term effects of three commonly prescribed antihypertensive drug classes (beta-blockers, ACE inhibitors, and calcium channel blockers) on postural balance and fall risk in adults with newly diagnosed primary hypertension. The main questions it aims to answer are:
* Do different antihypertensive drugs affect objective balance performance and fall risk?
* What are the effects of these medications on dizziness and fear of falling?
Researchers will use a balance analysis system (Biodex Balance System) and self-reported scales (Dizziness Handicap Inventory and Falls Efficacy Scale) to assess outcomes. Participants will:
* Be randomly assigned to one of three drug groups (metoprolol, ramipril, or amlodipine)
* Be evaluated at baseline (prior to treatment), at 2 weeks, and at 4 weeks after starting treatment
* Complete balance tests and questionnaires at each time point
This study aims to provide clinical insight into how commonly used blood pressure medications may impact balance and fall risk in real-world settings.
- Detailed Description
Falls and balance impairments are significant health concerns, particularly in individuals with hypertension who may be starting pharmacological treatment. Some antihypertensive drugs are known to cause side effects such as dizziness, postural hypotension, and impaired balance, all of which can increase fall risk. Despite this, comparative evidence on the short-term impact of different antihypertensive drug classes on postural balance remains limited.
This randomized controlled trial aims to compare the effects of three first-line antihypertensive drug classes-beta-blockers (e.g., metoprolol), ACE inhibitors (e.g., ramipril), and calcium channel blockers (e.g., amlodipine)-on postural stability and fall risk during the initial four weeks of treatment. Participants will be individuals aged 18-75 years who have been newly diagnosed with primary hypertension and have not previously used antihypertensive medications.
Assessments will be conducted using both objective and subjective measures. Objective balance evaluations will be performed using the Biodex Balance System, including the Fall Risk Test, Postural Stability Test (overall, anterior-posterior, and medial-lateral stability indices), and the Clinical Test of Sensory Interaction on Balance (CTSIB). Subjective assessments will include the Falls Efficacy Scale (FES) to evaluate fear of falling and the Dizziness Handicap Inventory (DHI) to assess the impact of dizziness on daily life.
The trial will include three evaluation time points: baseline (before starting treatment), week 2, and week 4. By providing a multidimensional assessment of balance performance, the study seeks to identify potential safety concerns and guide clinicians in making informed treatment decisions based on both cardiovascular and postural health.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 186
- Aged between 18 and 75 years
- Newly diagnosed with primary hypertension
- No prior use of antihypertensive medication
- No history of neurological, vestibular, orthopedic, or psychiatric conditions affecting balance
- Able to walk independently without assistive devices
- Provided written informed consent to participate in the study
- Secondary hypertension
- Known diagnosis of vestibular disorders (e.g., BPPV, Ménière's disease)
- Use of medications that may affect balance (e.g., sedatives, psychotropic drugs)
- History of falls due to trauma unrelated to balance
- Cognitive impairment preventing proper test participation
- Inability to complete the assessments at follow-up timepoints (2nd and 4th week)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Beta Blocker Group Beta Blocker Participants will receive a beta blocker (e.g., Metoprolol) for antihypertensive treatment. ACE Inhibitor Group ACE inhibitor Participants will receive an ACE inhibitor (e.g., Ramipril) for antihypertensive treatment. Calcium Channel Blocker Group Calcium channel blocker Participants will receive a calcium channel blocker (e.g., Amlodipine) for antihypertensive treatment.
- Primary Outcome Measures
Name Time Method Fall Risk Score (Biodex Balance System) Baseline (T0), Week 2 (T1), Week 4 (T2) Objective assessment of fall risk using the Fall Risk Test on the Biodex Balance System. Higher scores indicate greater fall risk.
- Secondary Outcome Measures
Name Time Method Postural Stability Indices (OSI, APSI, MLSI) Baseline (T0), Week 2 (T1), Week 4 (T2) Stability scores reflecting anterior-posterior and medial-lateral sway during standing, measured by the Biodex Balance System.
Sensory Integration Scores (CTSIB) Baseline (T0), Week 2 (T1), Week 4 (T2) Composite scores from the Clinical Test of Sensory Interaction on Balance, measuring sensory contributions to balance.
Falls Efficacy Scale (FES) Score Baseline (T0), Week 2 (T1), Week 4 (T2) Self-reported fear of falling during daily activities, total score ranges from 10 to 40.
Dizziness Handicap Inventory (DHI) - Total and Subscale Scores Baseline (T0), Week 2 (T1), Week 4 (T2) Measures physical, emotional, and functional impact of dizziness. Total score range: 0-100.
Trial Locations
- Locations (1)
Bolu Abant Izzet Baysal University, Izzet Baysal Training and Research Hospital
🇹🇷Bolu, Turkey
Bolu Abant Izzet Baysal University, Izzet Baysal Training and Research Hospital🇹🇷Bolu, Turkey