Axis Length and Its Relationship With Refractive Error in Chinese University Students

Completed

• Conditions: Refractive Error - Myopia Axial
• Interventions: Other: myopia or not myopia

• Registration Number: NCT04666870
• Lead Sponsor: Wang Hongxia

Brief Summary

To investigate the relationship between axis length (AL) and refractive error. eyes of low hyperopia to emmetropia subjects, comprising eyes with moderate to high myopia (-11.00D ≤ SE ≤ -4.00D) were analyzed in this cross-sectional study. Cycloplegic refractive error was measured with the autorefractor, AL was measured with the IOL master. Association between AL and refractive error were evaluated by linear regression analysis. The mean of AL and its correlation with SE, sex, and age were evaluated.

Detailed Description

To investigate the relationship between axis length (AL) and refractive error (RE). 894 eyes with low hyperopia to emmetropia (-0.50D ≤ spherical equivalent (SE) ≤ +2.00D), comprising 1007 eyes with moderate to high myopia (-11.00D ≤ SE ≤ -4.00D) were analyzed in this study. Cycloplegic RE was measured with the autorefractor, AL was measured with the IOL master. Association between AL and refractive error were evaluated by linear regression analysis. The mean of AL and its correlation with SE, sex, and age were evaluated.

Study Timeline

• Study Start: 2019-01-21
• Primary Completion: 2019-07-30
• Study Completion: 2019-08-11
• Study First Submitted: 2020-11-02
• Status Verified: 2020-12
• Study First Submitted QC: 2020-12-08
• Last Update Submitted: 2020-12-08
• Study First Posted: 2020-12-14
• Last Update Posted: 2020-12-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1901

Inclusion Criteria

with moderate to high myopia (SE ≤ -4.00D) without myopia (-0.50D ≤ spherical power ≤ +2.00D) no concurrent eye disease best corrected visual acuity is 1.0

Exclusion Criteria

significant systemic illnesses congenital myopia, media opacity uveitis glaucoma intraocular surgery refractive surgery neurologic diseases retinal disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
axis length	myopia or not myopia	1007 healthy students with moderate to high myopia (SE ≤ -4.00D) and 894 without myopia (-0.50D ≤ spherical power ≤ +2.00D) were enrolled.
gender	myopia or not myopia	male were 54.29% (N=1032), and female were 45.71% (N=869)

Primary Outcome Measures

Name	Time	Method
Axis length	from baseline at 6 months	Axis length change from baseline at 6 months
Refractive Error	from baseline at 6 months	Refractive Error change from baseline at 6 months

Trial Locations

Locations (1)

Shanghai Guanghua Integrated Traditional Chinese and Western Medicine Hospital; 🇨🇳 Shanghai, Shanghai, China