respiratory muscle activity during mechanical ventilation and spontaneous breathing trials

• Conditions: respiratory failure due to muscle weakness; 10028302; 10029317; 10024967

• Registration Number: NL-OMON41031
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

age >18 yr.
respiratory failure due to severe weakness of the respiratory muscles in absence of pulmonary disease (e.g. myasthenia, cervical spine injury)
respiratory failue de to severe weakness of the respiratory muscles with concomitant lung pathology (e.g. end stage ARDS, COPD and lung transplant)
ability to breathe spontaneously for 10 minutes
written informed consent

Exclusion Criteria

Reduced respiratory drive and inability to breath spontaneously without ventilator support for > 10 minutes
Hemodynamic instability defined as blood pressure below 100 / 60 mmHg
Air leaks by cannula or chest tubes: defined as leaks above 1 liter per minute
Severe hypoxemia defined as paO2 below 8 kPa
Esophagus or neck surgery

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The difference in activity of the respiratory muscles between the low and high<br /><br>assist level in mechanically ventilated critically ill patients admitted to<br /><br>the intensive care unit.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The difference in activity of the respiratory muscles between mechanical<br /><br>ventilation and spontaneous breathing in critically ill patients admitted to<br /><br>the intensive care uni</p><br>